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首页> 外文期刊>Journal of food protection >Utility of Combining Whole Genome Sequencing with Traditional Investigational Methods To Solve Foodborne Outbreaks of Salmonella Infections Associated with Chicken: A New Tool for Tackling This Challenging Food Vehicle
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Utility of Combining Whole Genome Sequencing with Traditional Investigational Methods To Solve Foodborne Outbreaks of Salmonella Infections Associated with Chicken: A New Tool for Tackling This Challenging Food Vehicle

机译：将全基因组测序与传统研究方法结合起来解决与鸡相关的食源性沙门氏菌感染的食源性暴发：解决这一具有挑战性的食物载体的新工具

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摘要

High consumption rates and a multitude of brands make multistate foodborne outbreaks of Salmonella infections associated with chicken challenging to investigate, but whole genome sequencing is a powerful tool that can be used to assist investigators. Whole genome sequencing of pathogens isolated from clinical, environmental, and food samples is increasingly being used in multistate foodborne outbreak investigations to determine with unprecedented resolution how closely related these isolates are to one another genetically. In 2014, federal and state health officials investigated an outbreak of 146 Salmonella Heidelberg infections in 24 states. A follow-up analysis was conducted after the conclusion of the investigation in which 27 clinical and 24 food isolates from the outbreak underwent whole genome sequencing. These isolates formed seven clades, the largest of which contained clinical isolates from a subcluster of case patients who attended a catered party. One isolate from a chicken processed by a large producer was closely related genetically (zero to three single-nucleotide polymorphism differences) to the clinical isolates from these subcluster case patients. Chicken from this large producer was also present in the kitchen of the caterer on the day before the event, thus providing additional evidence that the chicken from this producer was the outbreak source. This investigation highlights how whole genome sequencing can be used with epidemiologic and traceback evidence to identify chicken sources of foodborne outbreaks.
机译：高消费率和众多品牌使得与鸡相关的沙门氏菌多州食源性暴发难以调查，但全基因组测序是可用于协助研究人员的强大工具。从临床，环境和食物样本中分离出的病原体的全基因组测序正越来越多地用于多州食源性疾病暴发调查中，以前所未有的分辨率确定这些分离株在遗传上的密切关系。 2014年，联邦和州卫生官员调查了24个州的146例沙门氏菌海德堡感染暴发。调查结束后进行了后续分析，其中对来自暴发的27种临床分离株和24种食品分离株进行了全基因组测序。这些分离株形成了七个进化枝，其中最大的包含参加宴会的案例患者亚群的临床分离株。一家大型生产商加工的一只鸡的分离株与这些亚群病例患者的临床分离株在遗传上密切相关（零至三个单核苷酸多态性差异）。事件发生前一天，来自大型生产商的鸡肉也出现在了餐饮服务商的厨房中，因此提供了更多证据表明来自该生产商的鸡肉是疫源。这项研究强调了如何将全基因组测序与流行病学和追溯证据一起用于鉴定食源性暴发的鸡源。

著录项

  • 来源
    《Journal of food protection》 |2017年第4期|654-660|共7页
  • 作者

    SAMUEL J. CROWE; ALICE GREEN; KIMBERLY HERNANDEZ; VI PERALTA; LYNDSAY BOTTICHIO; STEPHANIE DEFIBAUGH-CHAVEZ; APHRODITE DOURIS; LAURA GIERALTOWSKI; KELLEY HISE; KAREN LA-PHAM; KAREN P. NEIL; MUSTAFA SIMMONS; GLENN TILLMAN; BETH TOLAR; DARLENE WAGNER; JAMIE WASILENKO; KRISTIN HOLT; EIJA TREES; MATTHEW E. WISE;

  • 作者单位

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

    U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, D.C. 20250;

    Kern County Public Health Services Department, Bakersfield, California 93301;

    California Department of Public Health, Richmond, California 94804, USA;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

    U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, D.C. 20250;

    U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, D.C. 20250;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

    Kern County Public Health Services Department, Bakersfield, California 93301;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

    U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, D.C. 20250;

    U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, D.C. 20250;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

    U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, D.C. 20250;

    U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, D.C. 20250;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    chicken; foodborne outbreak; salmonella; whole genome sequencing;

    机译：鸡;食源性暴发;沙门氏菌;全基因组测序;

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