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首页> 外文期刊>Journal of food protection >Effect of Probiotic Strains Lactobacillus acidophilus LAFTI L10 and Lactobacillus paracasei LAFTI L26 on Systemic Immune Functions and Bacterial Translocation in Mice
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Effect of Probiotic Strains Lactobacillus acidophilus LAFTI L10 and Lactobacillus paracasei LAFTI L26 on Systemic Immune Functions and Bacterial Translocation in Mice

机译：益生菌嗜酸乳杆菌LAFTI L10和副干酪乳杆菌LAFTI L26对小鼠全身免疫功能和细菌移位的影响

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The immunostimulatory effects of Lactobacillus acidophilus LAFTI L10 and Lactobacillus paracasei LAFTI L26 were evaluated to determine their probiotic properties for functional food applications. Mice were given oral doses of either L. acidophilus L10 or L. paracasei L26 (10~8 CFU/50 μl/day), and the effects on immune responses and bacterial translocation were assessed after the 14-day feeding trial. The proliferative responses of splenocytes to concanavalin A and lipopolysac-charide were significantly higher in mice fed L. acidophilus. Concanavalin A-induced splenocyte proliferative responses increased significantly in mice fed L. paracasei. Interleukin 10 and interferon γ production from the splenocytes stimulated with concanavalin A were enhanced in mice fed L. acidophilus or L. paracasei. The phagocytic activity of the peritoneal macrophages was significantly higher in mice fed either L. acidophilus or L. paracasei compared with control mice. In mice fed L. acidophilus or L. paracasei, the bacterial translocation of Lactobacillus spp. and total anaerobes to Peyer's patches and mesenteric lymph nodes was modulated compared with that in the control mice. Furthermore, there was no indication of disruption of intestinal mucosal integrity and thus no bacterial translocation to spleen, liver, or blood in mice fed either L. acidophilus or L. paracasei. The results of this study indicate that L. acidophilus and L. paracasei are potential enhancers of systemic immunity and are nonpathogenic, as suggested by their bacterial translocation profiles in healthy mice.
机译：评估了嗜酸乳杆菌LAFTI L10和副干酪乳杆菌LAFTI L26的免疫刺激作用，以确定它们在功能性食品中的益生特性。给小鼠口服嗜酸乳杆菌L10或副干酪乳杆菌L26（10〜8 CFU / 50μl/天），并在14天喂养试验后评估其对免疫应答和细菌易位的影响。在喂食嗜酸乳杆菌的小鼠中，脾细胞对伴刀豆球蛋白A和脂多糖的增殖反应明显更高。饲喂副干酪乳杆菌的小鼠伴刀豆球蛋白A诱导的脾细胞增殖反应显着增加。在喂食嗜酸乳杆菌或副干酪乳杆菌的小鼠中，伴刀豆球蛋白A刺激的脾细胞中白细胞介素10和干扰素γ的产生增加。与嗜酸乳杆菌或副干酪乳杆菌相比，喂食嗜酸乳杆菌或副干酪乳杆菌的小鼠腹膜巨噬细胞的吞噬活性显着更高。在嗜酸乳杆菌或副干酪乳杆菌的小鼠中，乳酸杆菌属的细菌易位。与对照组小鼠相比，Peyer斑块和肠系膜淋巴结的总厌氧菌得到调节。此外，在喂食嗜酸乳杆菌或副干酪乳杆菌的小鼠中，没有迹象表明肠粘膜完整性受到破坏，因此没有细菌向脾脏，肝脏或血液的移位。这项研究的结果表明，嗜酸乳杆菌和副干酪乳杆菌是系统性免疫的潜在增强剂，并且是非致病性的，正如健康小鼠中细菌易位谱所表明的那样。

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