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首页> 外文期刊>Journal of Food Science >Lycopene Ameliorated Oxidative Stress and Inflammation in Type 2 Diabetic Rats
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Lycopene Ameliorated Oxidative Stress and Inflammation in Type 2 Diabetic Rats

机译：番茄红素改善了2型糖尿病大鼠的氧化应激和炎症。

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We aim to study the antioxidative and anti-inflammatory effects of lycopene on type 2 diabetes mellitus (T2DM) rats, anticipating a complementary strategy for the prevention of long-term complications of T2DM. In this study, rats with streptozotocin-induced diabetes were divided into four groups, receiving a 10-week lycopene intervention: DM, DM + low dose of lycopene (L), DM + medium dose of lycopene (M), and DM + high dose of lycopene (H) group with 0, 5, 10, and 15 mg/kg BW lycopene, respectively. At the end of intervention, fasted blood glucose (FBG) level, oxidative stress indicators, including glycosylated hemoglobin (GHb), glycosylated low-density lipoprotein, oxidized low-density lipoprotein (ox-LDL). and malondialdehyde (MDA), as well as antioxidants, that is, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and inflammatory factors like tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP) were determined. The results indicated that oxidative stress and inflammatory factors were elevated in DM rats. Lycopene intervention decreased the FBG level in DM rats compared with the untreated ones. It revealed a dose-dependent effect on decreasing serum oxidative stress biomarkers, including GHb, ox-LDL, and MDA. Inflammatory factors (TNF-alpha and CRP) in DM rats were also decreased by lycopene intervention. Total antioxidative capacity as well as the activities of antioxidants in DM rats including CAT, SOD, and GPx were increased after lycopene intervention. We conclude that lycopene protects against diabetic progression and prevents further complications of diabetic rats through ameliorating oxidative stress and inflammation, as well as improving the systemic antioxidative capacity. Practical Application According to our study, lycopene intakes at experimental dosages appear to have beneficial effects on ameliorating oxidative stress and inflammation in type 2 diabetes mellitus (T2DM) rats, suggesting that lycopene might help improving T2DM progression when its daily intake is up to about 0.79 mg/kg BW in humans, which approximately equals to 5 mg/kg BW in rats. However, more clinical trials are needed to provide a more reliable and convincing conclusion in humans.
机译：我们旨在研究番茄红素对2型糖尿病（T2DM）大鼠的抗氧化和抗炎作用，以期为预防T2DM的长期并发症提供补充策略。在这项研究中，链脲佐菌素诱发的糖尿病大鼠分为四组，分别接受为期10周的番茄红素干预：DM，DM +低剂量的番茄红素（L），DM +中等剂量的番茄红素（M）和DM +高剂量剂量的番茄红素（H）组分别为0、5、10和15 mg / kg BW番茄红素。干预结束时，空腹血糖（FBG）水平，氧化应激指标，包括糖基化血红蛋白（GHb），糖基化低密度脂蛋白，氧化型低密度脂蛋白（ox-LDL）。和丙二醛（MDA）以及抗氧化剂，即过氧化氢酶（CAT），超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx），以及炎症因子，例如肿瘤坏死因子-α（TNF-alpha）和C反应性测定蛋白（CRP）。结果表明，DM大鼠的氧化应激和炎症因子升高。与未治疗的大鼠相比，番茄红素的干预降低了DM大鼠的FBG水平。它揭示了对降低血清氧化应激生物标记物（包括GHb，ox-LDL和MDA）的剂量依赖性作用。番茄红素的干预还可以减少DM大鼠的炎症因子（TNF-α和CRP）。番茄红素干预后，DM大鼠（包括CAT，SOD和GPx）的总抗氧化能力以及抗氧化剂的活性增加。我们得出的结论是，番茄红素通过改善氧化应激和炎症反应以及改善全身抗氧化能力，可以预防糖尿病的进展并预防糖尿病大鼠的进一步并发症。实际应用根据我们的研究，以实验剂量摄入的番茄红素似乎对缓解2型糖尿病（T2DM）大鼠的氧化应激和炎症具有有益的作用，这表明番茄红素在每日摄入量高达0.79左右时可能有助于改善T2DM的进展。毫克/千克体重，约等于5毫克/千克体重。然而，需要更多的临床试验来提供更可靠和令人信服的结论。

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