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首页> 外文期刊>Journal of Food Science >Interactions of Dihydromyricetin, a Flavonoid from Vine Tea (Ampelopsis grossedentata) with Gut Microbiota
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Interactions of Dihydromyricetin, a Flavonoid from Vine Tea (Ampelopsis grossedentata) with Gut Microbiota

机译：藤茶中的类黄酮二氢杨梅素与肠道菌群的相互作用

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摘要

Dihydromyricetin (DMY) is the main bioactive constituent in vine tea (Ampelopsis grossedentata), which was predominantly distributed in the gastrointestinal tract and showed poor oral bioavailability. Our aim was to systematically investigate the interactions of DMY with gut microbiota. Through the metabolism study of DMY by fecal microflora in vitro, it was found that DMY could be metabolized into three metabolites by fecal microflora via reduction and dehydroxylation pathways, and the dehydroxylation metabolite was the dominant one. Meanwhile, in order to consider the influence of gut microbiota metabolism on the pharmacokinetics of DMY, the pharmacokinetics of DMY in control and pseudo-germ-free rats were compared. It was shown that area under the curve (AUC) could only slightly increase, however, peak concentration (C_(max)) could significantly increase in the pseudo-germ-free rats compared with the control rats, which indicated the gut microbiota metabolism played an important role in the pharmacokinetics of DMY. In addition, the long-term influence of DMY on gut microbiota composition by using 16S rRNA pyrosequencing was further investigated. And it was found that DMY could markedly alter the richness and diversity of the gut microbiota and modulate the gut microbiota composition. The present findings will be helpful for the future development and clinical application of DMY.
机译：二氢杨梅素（DMY）是藤茶（Ampelopsis grossedentata）中的主要生物活性成分，主要分布在胃肠道中，口服生物利用度较差。我们的目的是系统地研究DMY与肠道菌群的相互作用。通过粪便微生物区系对DMY的代谢研究，发现DMY可以通过还原和脱羟基途径被粪便微生物区系代谢成3种代谢产物，其中脱羟基代谢产物为主要代谢产物。同时，为了考虑肠道菌群代谢对DMY药代动力学的影响，比较了DMY在对照和无假胚大鼠中的药代动力学。结果表明，与对照大鼠相比，无假细菌的大鼠曲线下面积（AUC）只能略微增加，但是峰值浓度（C_（max））则可以显着增加，这表明肠道菌群的代谢发挥了作用。在DMY的药代动力学中起重要作用。此外，通过使用16S rRNA焦磷酸测序进一步研究了DMY对肠道菌群组成的长期影响。并且发现DMY可以显着改变肠道菌群的丰富性和多样性并调节肠道菌群的组成。目前的发现将有助于DMY的未来发展和临床应用。

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  • 来源
    《Journal of Food Science》 |2018年第6期|1444-1453|共10页
  • 作者

    Li Fan; Xinyuan Zhao; Qing Tong; Xiya Zhou; Jing Chen; Wei Xiong; Jianguo Fang; Wenqing Wang; Chunyang Shi;

  • 作者单位

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

    Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    dihydromyricetin; gut microbiota composition; gut microbiota metabolism; pharmacokinetics;

    机译：二氢杨梅素肠道菌群组成;肠道菌群代谢药代动力学;

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