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首页> 外文期刊>Journal of Food Science >Extraction and Separation of Volatile and Fixed Oils from Seeds of Myristica fragrans by Supercritical CO_2: Chemical Composition and Cytotoxic Activity on Caco-2 Cancer Cells
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Extraction and Separation of Volatile and Fixed Oils from Seeds of Myristica fragrans by Supercritical CO_2: Chemical Composition and Cytotoxic Activity on Caco-2 Cancer Cells

机译：超临界CO_2提取和分离肉豆蔻种子中的挥发油和不挥发油：对Caco-2癌细胞的化学组成和细胞毒活性

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摘要

Isolation of volatile and fixed oils from nutmeg have been obtained by supercritical fractioned extraction with carbon dioxide. Extraction experiments were carried out at pressures of 90 and 250 bar and temperature of 40 ℃. The extraction step performed at 90 bar produced a volatile fraction mainly formed by myristicin (32.8%), sabinene (16.1%), α-pinene (9.8%), β-pinene (9.4%), β-phellandrene (4.9%), safrole (4.1%) and terpinen-4-ol (3.6%). The oil yield relative to this step of the process was 1.4% by weight of the charge. The last extraction step at 250 bar produced a butter-like material (nutmeg butter). The yield of this step was 14.4% by weight. The most represented fatty acids of fixed oil from nutmeg were 14:0 (79.2%), 18:1 n-9 (7.4%) and 16:0 (6.1%), and in particular the unsaturated fatty acids 18:1 n-9 averaged 32.96 μg/mg of oil. The level of myristicin in the nutmeg essential and fixed oils was also directly quantified by reversed HPLC-DAD. Moreover, the essential oil obtained from nutmeg, as well as myristicin, showed a significant in vitro inhibitory effect on the growth of a colon cancer cell line (undifferentiated Caco-2 cells).
机译：通过用二氧化碳进行超临界分馏，可以从肉豆蔻中分离出挥发油和不挥发油。萃取实验在90和250 bar的压力和40℃的温度下进行。在90巴下进行的萃取步骤产生的挥发分主要由肉豆蔻苷（32.8％），sa烯（16.1％），α-pine烯（9.8％），β-pine烯（9.4％），β--烯（4.9％），黄樟脑（4.1％）和萜品四醇（3.6％）。相对于该方法的该步骤的油产率为进料的1.4重量％。在250 bar的最后萃取步骤产生了一种黄油状物质（肉豆蔻黄油）。该步骤的产率为14.4重量％。来自肉豆蔻的不挥发性油中最具代表性的脂肪酸是14：0（79.2％），18：1 n-9（7.4％）和16：0（6.1％），尤其是不饱和脂肪酸18：1 n- 9平均为32.96μg/ mg油。肉豆蔻精油和固定油中肉豆蔻苷的含量也可以通过反相HPLC-DAD直接定量。此外，从肉豆蔻以及肉豆蔻素获得的精油对结肠癌细胞系（未分化的Caco-2细胞）的生长表现出显着的体外抑制作用。

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  • 来源
    《Journal of Food Science》 |2012年第6期|p.C448-C453|共6页
  • 作者

    Alessandra Piras; Antonella Rosa; Bruno Marongiu; Angela Atzeri; M. Assunta Dessi; Danilo Falconieri; Silvia Porcedda;

  • 作者单位

    Dipto. di Scienze Chimiche, Univ. degli Studi di Cagliari, Cittadella Univ. di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy;

    Dipto. di Biologia Sperimentale, Sezione di Patologia Sperimentale, Univ. degli Studi di Cagliari, Cittadella Univ. di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy;

    Dipto. di Scienze Chimiche, Univ. degli Studi di Cagliari, Cittadella Univ. di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy;

    Dipto. di Biologia Sperimentale, Sezione di Patologia Sperimentale, Univ. degli Studi di Cagliari, Cittadella Univ. di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy;

    Dipto. di Biologia Sperimentale, Sezione di Patologia Sperimentale, Univ. degli Studi di Cagliari, Cittadella Univ. di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy;

    Dipto. di Scienze Chimiche, Univ. degli Studi di Cagliari, Cittadella Univ. di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy;

    Dipto. di Scienze Chimiche, Univ. degli Studi di Cagliari, Cittadella Univ. di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cytotoxic activity; essential oil; fixed oil; myristica fragrans; supercritical extraction;

    机译：细胞毒活性;香精油;固定油;肉豆蔻超临界萃取;

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