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首页> 外文期刊>Journal of Hazardous Materials >Developmental toxicity of fipronil in early development of zebrafish (Danio rerio) larvae: Disrupted vascular formation with angiogenic failure and inhibited neurogenesis
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Developmental toxicity of fipronil in early development of zebrafish (Danio rerio) larvae: Disrupted vascular formation with angiogenic failure and inhibited neurogenesis

机译：氟虫腈在斑马鱼（Danio rerio）幼虫早期发育中的发育毒性：破坏血管形成，引起血管生成衰竭并抑制神经发生

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Fipronil has been widely used in agriculture to prevent aggressive insects from damaging agricultural products. Fipronil residues circulate in the environment and they have been detected in non-targeted organisms in aquatic environments. To study the effect of fipronil toxicity on environmental health, 6 h post fertilization (hpf) zebrafish embryos were treated with fipronil for 72 h. LC50 value was obtained by applying varying concentrations of fipronil to zebrafish embryos for 72 h. As zebrafish embryos are useful vertebrate models for studying developmental and genetic findings in toxicology research, they were exposed to fipronil to study detailed elucidating mechanisms with hazardous end points of toxicity. Cell cycle arrest-related apoptosis supported pathological alterations, such as increased mortality, shortened body length, and reduced hatchability. Furthermore, observed heart defects, including edema and irregular heartbeat were caused due to abnormal blood circulation. In transgenic zebrafish models (fli1:eGFP and olig2:dsRED), disrupted blood vessel formations were indicated by eGFP(+) endothelial cells. Moreover, neurogenic defects were observed by studying dsRED(+) motor neurons and oligodendrocytes. This study demonstrates fipronil accumulation in aquatic environment and its ability to impair essential processes, such as angiogenesis and neurogenesis during early developmental stage of zebrafish, along with general developmental toxicity.
机译：Fipronil已广泛用于农业中，以防止侵蚀性昆虫破坏农产品。 Fipronil残留物在环境中循环，已在水生环境中的非目标生物中检测到它们。为了研究氟虫腈毒性对环境健康的影响，在受精（hpf）后的6 h斑马鱼胚胎中，用氟虫腈处理了72 h。 LC50值是通过将不同浓度的氟虫腈应用于斑马鱼胚胎72小时而获得的。由于斑马鱼胚胎是有用的脊椎动物模型，可用于研究毒理学研究中的发育和遗传发现，因此将它们暴露于氟虫腈以研究详细的阐明机制以及有害的毒性终点。细胞周期停滞相关的细胞凋亡支持病理改变，例如死亡率增加，体长缩短和孵化率降低。此外，观察到的心脏缺陷包括水肿和心律不齐是由于血液循环异常引起的。在转基因斑马鱼模型（fli1：eGFP和olig2：dsRED）中，eGFP（+）内皮细胞表明血管形成受到破坏。此外，通过研究dsRED（+）运动神经元和少突胶质细胞观察到神经源性缺陷。这项研究证明了氟虫腈在水生环境中的蓄积及其在斑马鱼早期发育阶段损害诸如血管生成和神经发生等基本过程的能力，以及一般的发育毒性。

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