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首页> 外文期刊>Journal of Hazardous Materials >Potential toxic effects of 4-OH-chlorothalonil and photodegradation product on human skin health
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Potential toxic effects of 4-OH-chlorothalonil and photodegradation product on human skin health

机译：4-OH-氯洛尼尼尔和光降解产物对人体皮肤健康的潜在毒性作用

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摘要

Chlorothalonil (CHT) is widely used in agriculture as a fungicide and has been detected in various ecosystems along with its degradation products. A primary intermediate product of degradation, 4-hydroxychlorothalonil (4-OH-CHT) has demonstrated toxic effects on aquatic organisms. However, the toxic effects of 4-OH-CHT on human health and the impacts of environmental factors on the toxicity remain unclear. To understand the environmental modification on the toxicity of 4-OH-CHT to human health, we used a three-dimensional human skin culture model. 4-OH-CHT and irradiated 4-OH-CHT were applied to the model for the dermatoxicity analyses. Although neither the 4-OH-CHT nor the irradiated 4-OH-CHT inhibited the cell proliferation, the 4-OH-CHT significantly attenuated the keratinocyte migration by 26% at a concentration of 20 ppb and by 44 % at 100 ppb. The 4-OH-CHT also demonstrated inhibitory effects on keratinocyte differentiation at both 20 ppb and 100 ppb. In contrast, photodegraded 4-OH-CHT did not show inhibitory effects on the migration and differentiation of the keratinocytes at any concentration. Similarly, the 4-OH-CHT treated 3D keratinocyte culture dramatically activated the co-cultured dermal fibroblast cells by increasing the production of alpha smooth muscle actin (alpha-SMA) and pro-Collagen I alpha. The mRNA levels of these two proteins were upregulated by 1.13 and 10.97 folds with the stimulation of 100 ppb 4-OH-CHT. The protein level of pro-Collagen Ia in dermal fibroblast cells was increased by 68 % with 100 ppb 4-OH-CHT. The photodegraded 4-OH-CHT failed to activate the co-cultured fibroblast cells. The 4-OH-CHT also enhanced pro-inflammatory cytokine production in keratinocytes compared to the photodegraded products. These results suggest that exposure to environmental 4-OH-CHT could increase the risk of inflammatory skin diseases in humans.
机译：Chlorothalonil（CHT）广泛用于农业作为杀真菌剂，并在各种生态系统中检测到其降解产物。初级中间产物降解，4-羟基氯洛洛尼洛（4-OH-CHT）对水生生物进行了毒性作用。然而，4-OH-CHT对人体健康的毒性和环境因素对毒性的影响仍然尚不清楚。要了解对人体健康4 oh-cht的毒性的环境改性，我们使用了三维人体皮肤培养模型。将4-OH-CHT和照射的4-OH-CHT应用于皮肤毒性分析的模型。虽然4-OH-CHT NOR辐照的4-OH-CHT都不抑制细胞增殖，但是4-OH-CHT在浓度为20ppb的浓度下显着减弱了角质形成细胞迁移26％，在100ppb下达到44％。 4-OH-CHT还表现出对20ppb和100ppb的棘突细胞分化的抑制作用。相比之下，光降解的4-OH-CHT没有显示出对任何浓度的角蛋白细胞的迁移和分化的抑制作用。类似地，4-OH-CHT处理的3D角质形成细胞培养物通过增加α平滑肌肌动蛋白（α-SMA）和Pro-Collagen Iα的产生而显着地活化了共培养的皮肤成纤维细胞。将这两种蛋白质的mRNA水平升高为1.13和10.97折叠，刺激100ppb 4-OH-CHT。皮肤成纤维细胞中的蛋白质水平增加68％，100ppb 4-OH-CHT增加了68％。光降解的4-OH-CHT未能激活共培养的成纤维细胞。与光降光的产品相比，4-OH-CHT还增强了角质形成细胞的促炎细胞因子产生。这些结果表明，暴露于环境4-OH-CHT可以增加人类炎症皮肤病的风险。

著录项

  • 来源
    《Journal of Hazardous Materials》 |2020年第jul15期|122575.1-122575.11|共11页
  • 作者

    Xu Wei; Vebrosky Emily N.; Armbrust Kevin L.;

  • 作者单位

    Texas A&M Univ Corpus Christi Coll Sci & Engn Dept Life Sci Corpus Christi TX USA;

    Louisiana State Univ Coll Coast & Environm Dept Environm Sci Baton Rouge LA 70803 USA;

    Louisiana State Univ Coll Coast & Environm Dept Environm Sci Baton Rouge LA 70803 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    4-hydroxychlorothalonil; Human skin; Photodegradation; Inflammatory skin diseases;

    机译：4-羟基氯疗外;人体皮肤;光降解;炎症皮肤病;

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