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Bottom-line mechanism of organochlorine pesticides on mitochondria dysfunction linked with type 2 diabetes

机译：有机氯农药对线粒体功能障碍与2型糖尿病有功能障碍的底线机制

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摘要

Environmental pollution by anthropogenic chemicals has become a considerable problem. Organochlorine pesticides (OCPs), a subclass of persistent organic pollutants, are used as insecticides and industrial chemicals. They are lipophilic and minimally degradable, and they easily accumulate in the environment and human body. Epidemiological studies have demonstrated that exposure to OCPs strongly correlates with the development of type 2 diabetes, which involves mitochondrial dysfunction. To clarify their effects, OCP mixtures (beta-hexachlorocyclohexane, heptachlor, hexachlorobenzene, 4,4'-DDT, and chlordane) were used to treat mitochondria from zebrafish livers. Results showed that as OCP concentrations increased, Ca2+ intake into the mitochondria rose, which increased the activity of mitochondrial complexes I, II, IV, and citrate synthase. Complex III yielded the opposite result because the OCP mixture mimicked decylubiquinol, a natural substrate of complex III. Our results reflect the actual state of toxins, non-monotonic, in the environment, which is important for determining the consequences of OCPs on mitochondrial dysfunction.
机译：人为化学品的环境污染已成为一个相当大的问题。有机氯杀虫剂（OCP），持续有机污染物的亚类，用作杀虫剂和工业化学品。它们是亲脂性和最小可降解的，它们容易积聚在环境和人体中。流行病学研究表明，暴露于ocps与2型糖尿病的发育强烈关联，涉及线粒体功能障碍。为了阐明它们的作用，使用OCP混合物（β-六氯环己烷，庚烷，六氯苯，4,4'-DDT和氯丁烷）从斑马鱼肝脏治疗线粒体。结果表明，随着OCP浓度的增加，Ca2 +摄入线粒体升至线粒体升高，这增加了线粒体复合物I，II，IV和柠檬酸酯合酶的活性。复合物III产生相反的结果，因为OCP混合物模仿甲基喹啉，络合物III的天然基质。我们的结果反映了毒素，非单调，环境中的实际状态，这对于确定ocps对线粒体功能障碍的后果非常重要。

著录项

  • 来源
    《Journal of Hazardous Materials》 |2020年第jul5期|122400.1-122400.9|共9页
  • 作者

    Ko Eun; Choi Moonsung; Shin Sooim;

  • 作者单位

    Chonnam Natl Univ Coll Engn Interdisciplinary Program Bioenergy & Biomat Grad Gwangju 61186 South Korea;

    Seoul Natl Univ Sci & Technol Coll Energy & Biotechnol Dept Optometry Seoul 01811 South Korea|Seoul Natl Univ Sci & Technol Convergence Inst Biomat & Bioengn Seoul 01811 South Korea;

    Chonnam Natl Univ Coll Engn Interdisciplinary Program Bioenergy & Biomat Grad Gwangju 61186 South Korea|Chonnam Natl Univ Coll Engn Dept Biotechnol & Bioengn 77 Yongbong Ro Gwangju 61186 South Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Competitive inhibitor; Diabetes; Ion regulator; Mitochondrial dysfunction; Organochlorine pesticides (OCPs);

    机译：竞争性抑制剂;糖尿病;离子调节器;线粒体功能障碍;有机氯杀虫剂（OCP）;

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