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首页> 外文期刊>Journal of Hazardous Materials >A critical review on genotoxicity potential of low dimensional nanomaterials
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A critical review on genotoxicity potential of low dimensional nanomaterials

机译：低维纳米材料的基因毒性潜力的关键综述

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摘要

Low dimensional nanomaterials (LDNMs) have earned attention among researchers as they exhibit a larger surface area to volume and quantum confinement effect compared to high dimensional nanomaterials. LDNMs, including 0-D and 1-D, possess several beneficial biomedical properties such as bioimaging, sensor, cosmetic, drug delivery, and cancer tumors ablation. However, they threaten human beings with the adverse effects of cytotoxicity, carcinogenicity, and genotoxicity when exposed for a prolonged time in industry or laboratory. Among different toxicities, genotoxicity must be taken into consideration with utmost importance as they inherit DNA related disorders causing congenital disabilities and malignancy to human beings. Many researchers have performed NMs' genotoxicity using various cell lines and animal models and reported the effect on various physicochemical and biological factors. In the present work, we have compiled a comparative study on the genotoxicity of the same or different kinds of NMs. Notwithstanding, we have included the classification of genotoxicity, mechanism, assessment, and affecting factors. Further, we have highlighted the importance of studying the genotoxicity of LDNMs and signified the perceptions, future challenges, and possible directives in the field.
机译：低尺寸纳米材料（LDNMS）在研究人员之间赢得了关注，因为与高尺寸纳米材料相比，研究人员在对体积和量子限制效果上表现出更大的表面积和量子限制效果。 LDNMS，包括0-D和1-D，具有若干有益的生物医学性质，如生物影像体，传感器，化妆品，药​​物递送和癌症肿瘤消融。然而，它们在暴露于工业或实验室的延长时间时，他们威胁着细胞毒性，致癌性和遗传毒性的不良反应。在不同的毒性中，必须以最重要的是，遗传与人类引起先天性残疾和恶性肿瘤的最重要的毒性。许多研究人员使用各种细胞系和动物模型进行了NMS的遗传毒性，并报告了对各种物理化学和生物因素的影响。在目前的工作中，我们编制了对相同或不同类型的NMS的基因毒性的比较研究。尽管如此，我们已经包括基因毒性，机制，评估和影响因素的分类。此外，我们强调了研究LDNMS的遗传毒性的重要性，并意味着该领域中的观念，未来挑战和可能的指示。

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