The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms

Qiu Wenhui; Liu Shuai; Chen Honghong; Luo Shusheng; Xiong Ying; Wang Xuejing; Xu Bentuo; Zheng Chunmiao; Wang Ke-Jian

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The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms

机译：BPA，BPB，BPS，BPF和BPAF对斑马鱼胚胎生殖神经内分泌系统的比较毒性及其机制

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Bisphenol A (BPA) is a well-known endocrine disruptor that has elicited great concern because of its potential toxic effects in organisms. In this study, the effects of BPA and several BPA structural analogs, including BPB, BPS, BPF, and BPAF, on the reproductive neuroendocrine system were evaluated during zebrafish embryonic and larval development. Our results showed that the numbers of gonadotropin-releasing hormone 3 neurons in zebrafish embryos increased after 100 mu g/L BPA analog treatment, and exposure to BPA or its analogs at 1 or 100 mu g/L increased the expression of reproductive neuroendocrine-related genes and the levels of typical hormones such as LH, FSH, E2, and GH. Moreover, the effects were associated with increases in the activities of er alpha, er beta, and cyp19a genes. The respective estrogen receptors (ER) and aromatase (AROM) antagonists significantly attenuated the stimulation of lh beta, fsh beta, LH, and FSH expression, thereby proving that BPA analogs affect the reproductive neuroendocrine system via ERs and AROM pathway. Furthermore, we observed that the reproductive neuroendocrine toxicity of BPAF was more similar to that of BPA. This was the first study to comparatively explore the reproductive neuroendocrine toxicities of bisphenols in aquatic organism.

机译：双酚A（BPA）是一种众所周知的内分泌干扰，因此由于其在生物体中的潜在毒性作用而引起了极大的关注。在本研究中，在斑马鱼胚胎和幼虫发育期间评估了BPA和几种BPA结构类似物，包括BPB，BPS，BPF和BPAF，包括BPB，BPS，BPF和BPAF，在生殖神经内分泌系统中评估。我们的研究结果表明，斑马鱼胚胎中的促性腺激素释放激素3神经元的数量在100μg/ l BPA模拟治疗后增加，并且在1或100μg/ l的BPA或其类似物暴露增加生殖神经内分泌相关的表达基因和典型激素等水平，如LH，FSH，E2和GH。此外，该效果与ERα，ERβ和CYP19A基因的活性的增加有关。相应的雌激素受体（ER）和芳族酶（AROM）拮抗剂显着减弱了LHβ，FSHβ，LH和FSH表达的刺激，从而证明BPA类似物通过ERS和AROM途径影响生殖神经内分泌系统。此外，我们观察到BPAF的繁殖神经内分泌毒性与BPA的生殖神经内分泌毒性更类似于BPA。这是第一项探讨水生生物中双酚生殖神经内分泌毒性的研究。

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《Journal of Hazardous Materials》 |2021年第15期|124303.1-124303.11|共11页
作者
Qiu Wenhui; Liu Shuai; Chen Honghong; Luo Shusheng; Xiong Ying; Wang Xuejing; Xu Bentuo; Zheng Chunmiao; Wang Ke-Jian;
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Southern Univ Sci & Technol Guangdong Prov Key Lab Soil & Groundwater Pollut State Environm Protect Key Lab Integrated Surface Sch Environm Sci & Engn Shenzhen 518055 Peoples R China|Southern Univ Sci & Technol Shenzhen Municipal Engn Lab Environm IoT Technol Shenzhen 518055 Guangdong Peoples R China|Xiamen Univ State Key Lab Marine Environm Sci Xiamen 361102 Peoples R China;

Jiangxi Acad Sci Res Inst Poyang Lake Nanchang 330012 Jiangxi Peoples R China;

Southern Univ Sci & Technol Guangdong Prov Key Lab Soil & Groundwater Pollut State Environm Protect Key Lab Integrated Surface Sch Environm Sci & Engn Shenzhen 518055 Peoples R China;

Southern Univ Sci & Technol Guangdong Prov Key Lab Soil & Groundwater Pollut State Environm Protect Key Lab Integrated Surface Sch Environm Sci & Engn Shenzhen 518055 Peoples R China;

Southern Univ Sci & Technol Guangdong Prov Key Lab Soil & Groundwater Pollut State Environm Protect Key Lab Integrated Surface Sch Environm Sci & Engn Shenzhen 518055 Peoples R China;

Southern Univ Sci & Technol Guangdong Prov Key Lab Soil & Groundwater Pollut State Environm Protect Key Lab Integrated Surface Sch Environm Sci & Engn Shenzhen 518055 Peoples R China;

Wenzhou Univ Sch Life & Environm Sci Wenzhou 325035 Peoples R China;

Southern Univ Sci & Technol Guangdong Prov Key Lab Soil & Groundwater Pollut State Environm Protect Key Lab Integrated Surface Sch Environm Sci & Engn Shenzhen 518055 Peoples R China;

Xiamen Univ State Key Lab Marine Environm Sci Xiamen 361102 Peoples R China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
BPA analogs; Reproductive Neuroendocrine system; Estrogen receptor; Enzyme Aromatase; Zebrafish embryos;

机译：BPA类似物;繁殖神经内分泌系统;雌激素受体;酶芳香酶;斑马鱼胚胎;

The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms

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