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首页> 外文期刊>Journal of Hazardous Materials >Removal of antiretroviral drugs stavudine and zidovudine in water under UV_(254) and UV_(254)/H_2O_2 processes: Quantum yields, kinetics and ecotoxicology assessment
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Removal of antiretroviral drugs stavudine and zidovudine in water under UV_(254) and UV_(254)/H_2O_2 processes: Quantum yields, kinetics and ecotoxicology assessment

机译：在UV_（254）和UV_（254）/ H_2O_2工艺下去除水中抗逆转录病毒药物司他夫定和齐多夫定：量子产率，动力学和生态毒理学评估

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摘要

The concentration of antiretroviral drugs in wastewater treatment plants (WWTP) effluents and surface waters of many countries has increased significantly due to their widespread use for HIV treatment. In this study, the removal of stavudine and zidovudine under UV254 photolysis or UV254/H2O2 was investigated in a micro capillary film (MCF) photoreactor, using minimal water samples quantities. The UV254 quantum yield of zidovudine, (2.357 +/- 0.0589).10(-2) mol ein(-1) (pH 4.0-8.0), was 28-fold higher that the yield of stavudine (8.34 +/- 0.334).10(-4) mol ein(-1) (pH 6.0-8.0). The second -order rate constant k(OH,i) of reaction of hydroxyl radical with the antiretrovirals (UV254/H2O2 process) were determined by kinetics modeling: (9.98 +/- 0.68).10(8) M-1 s(-1) (pH 4.0-8.0) for zidovudine and (2.03 +/- 0.18).10(9) M-1 s(-1) (pH 6.0-8.0) for stavudine. A battery of ecotoxicological tests (i.e. inhibition growth, bioluminescence, mutagenic and genotoxic activity) using bacteria (Aliivibrio fischeri, Salmonella typhimurium), crustacean (Daphnia magna) and algae (Raphidocelis subcapitata) revealed a marked influence of the UV dose on the ecotoxicological activity. The UV254/H2O2 treatment process reduced the ecotoxicological risk associated to direct photolysis of the anti-retrovirals aqueous solutions, but required significantly higher UV254 doses (= 2000 mJ cm(-2)) in comparison to common water UV disinfection processes.
机译：由于许多国家将其广泛用于HIV治疗，因此抗逆转录病毒药物在废水处理厂（WWTP）废水和地表水中的浓度已显着增加。在这项研究中，使用最小的水样量，在微毛细管膜（MCF）光反应器中研究了在UV254光解或UV254 / H2O2下去除司他夫定和齐多夫定的方法。齐多夫定的UV254量子产率（2.357 +/- 0.0589）.10（-2）mol ein（-1）（pH 4.0-8.0）比司他夫定的产率（8.34 +/- 0.334）高28倍.10（-4）mol ein（-1）（pH 6.0-8.0）。通过动力学模型确定羟基自由基与抗逆转录病毒药（UV254 / H2O2法）的反应的二级速率常数k（OH，i）：（9.98 +/- 0.68）.10（8）M-1 s（- 1）齐多夫定（pH 4.0-8.0）和司他夫定（2.06.0 +/- 0.18）.10（9）M-1 s（-1）（pH 6.0-8.0）。使用细菌（费氏疟原虫，鼠伤寒沙门氏菌），甲壳类（大蚤）和藻类（Raphidocelis subcapitata）进行的一系列生态毒理学测试（即抑制生长，生物发光，诱变和遗传毒性活性）表明，紫外线剂量对生态毒理学活性有显着影响。 UV254 / H2O2处理工艺降低了与抗逆转录病毒水溶液直接光解相关的生态毒理风险，但与普通的水紫外线消毒工艺相比，需要显着更高的UV254剂量（> = 2000 mJ cm（-2））。

著录项

  • 来源
    《Journal of Hazardous Materials》 |2018年第may5期|195-204|共10页
  • 作者

    Russo Danilo; Siciliano Antonietta; Guida Marco; Andreozzi Roberto; Reis Nuno M.; Li Puma Gianluca; Marotta Raffaele;

  • 作者单位

    Univ Naples Federico II, Dipartimento Ingn Chim Mat & Prod Ind, Ple V Tecchio 80, Naples, Italy;

    Univ Naples Federico II, Dipartimento Biol, Complesso Univ Monte St Angelo,Via Cinthia 4, Naples, Italy;

    Univ Naples Federico II, Dipartimento Biol, Complesso Univ Monte St Angelo,Via Cinthia 4, Naples, Italy;

    Univ Naples Federico II, Dipartimento Ingn Chim Mat & Prod Ind, Ple V Tecchio 80, Naples, Italy;

    Univ Bath, Dept Chem Engn, Bath BA2 7AY, Avon, England;

    Loughborough Univ Technol, Environm Nanocatalysis & Phororeact Engn Dept Che, Loughborough LE11 3TU, Leics, England;

    Univ Naples Federico II, Dipartimento Ingn Chim Mat & Prod Ind, Ple V Tecchio 80, Naples, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Photodegradation; Microreactor; Mutagenicity; Genotoxicity; Water reuse; Zidovudine; Stavudine; Antiretroviral;

    机译：光降解;微反应器;致突变性;遗传毒性;水回用;齐多夫定;司他夫定;抗逆转录病毒;

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