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Enhancement between environmental tobacco smoke and arsenic on emphysema-like lesions in mice

机译：环境烟草烟雾和砷对小鼠气肿样病变的增强作用

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摘要

Chronic obstructive pulmonary diseases (COPD) have been the major cause of mortality worldwide. Early identification of populations at risk allows us to prevent the occurrence and to reduce the cost of health care. In human studies, exposure to environmental tobacco smoke (ETS) and arsenic respectively increased the risk of chronic lung diseases, including COPD. We suspected that ETS and arsenic might enhance the risk of COPD. In our present study, we evaluated this hypothesis in mice and tried to identify early biomarkers for chemicals-induced lung lesions. Mice inhaled ETS and/or administrated arsenite via gavage for 4 weeks. At the end of experiment, exposure to ETS or arsenite alone failed to cause lung lesions or inflammation. However, co-exposure to ETS and arsenite significantly induced emphysema-like lesions, characterized with enlarged alveolar spaces and destruction of alveolar structure, although inflammation was not observed. Furthermore, co-exposure to ETS and arsenite significantly increased plasma 8-oxodeoxyguanosine (8-OHdG) levels. Our results indicated that co-exposure to ETS and arsenite induced emphysematous lesions, and plasma 8-OHdG might serve as an early biomarker for co-exposure of ETS and arsenite. With information about ETS and arsenic exposure in human populations, plasma 8-OHdG will help us to identify individuals at risk.
机译：慢性阻塞性肺疾病（COPD）已成为全球死亡的主要原因。尽早识别高危人群可以使我们预防这种情况的发生，并降低医疗保健的成本。在人体研究中，暴露于环境烟草烟雾（ETS）和砷分别增加了包括COPD在内的慢性肺部疾病的风险。我们怀疑ETS和砷可能会增加COPD的风险。在我们目前的研究中，我们评估了小鼠的这一假设，并试图找出化学物诱发的肺部病变的早期生物标记。小鼠通过管饲吸入ETS和/或施用亚砷酸盐4周。在实验结束时，仅暴露于ETS或亚砷酸盐无法引起肺部病变或炎症。然而，尽管未观察到炎症，但同时暴露于ETS和亚砷酸盐会明显诱发肺气肿样病变，其特征是肺泡间隙增大和肺泡结构破坏。此外，同时暴露于ETS和亚砷酸盐会显着增加血浆8-氧代脱氧鸟苷（8-OHdG）的水平。我们的结果表明，共同暴露于ETS和亚砷酸盐诱发的气肿性病变，血浆8-OHdG可能作为ETS和亚砷酸盐共同暴露的早期生物标志物。有了有关人群中ETS和砷暴露的信息，血浆8-OHdG将帮助我们识别有风险的个体。

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  • 来源
    《Journal of Hazardous Materials》 |2012年第30期|p.256-263|共8页
  • 作者

    Chien-Kai Wang; Hui-Ling Lee; Han Chang; Ming-Hsien Tsai; Yu-Chun Kuo; Pinpin Lin;

  • 作者单位

    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan. ROC;

    Department of Chemistry, Fujen Catholic University, 510 Zhongzheng Road, Xinzhuang District, New Taipei City 24205, Taiwan, ROC;

    Department of Pathology, School of Medicine, China Medical University, Taichung, Taiwan, ROC,Department of Pathology, China Medical University Hospital, Taichung, Taiwan, ROC;

    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan. ROC;

    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan. ROC;

    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Key an Road, Zhunan, Miaoli bounty 350, Taiwan, ROC.;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    chronic obstructive pulmonary diseases; arsenite; environmental tobacco smoking; plasma 8-oxodeoxyguanosine;

    机译：慢性阻塞性肺疾病;亚砷酸盐环保吸烟;血浆8-氧代脱氧鸟苷;

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