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In vivo screening to determine neurological hazards of nitrogen dioxide (NO_2) using Wistar rats

机译:使用Wistar大鼠进行体内筛查以确定二氧化氮(NO_2)的神经系统危害

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摘要

NO_2 is a well-known indoor and outdoor pollutant that may cause adverse health problems. Recently, accumulating but extremely limited evidences show that NO_2 possibly express neurotoxicity and is responsible for various neurological disorders. In the present study, neurological hazard of NO_2 and possible mechanisms were determined in rat pallium following a repetitive inhalation exposure with various concentrations (5,10 and 20mg/m~3). After 7-day exposure (6 h/day), observable adverse effects were induced encompassing decreased ratio of brain to body weight, mild brain pathology, increased neuronal apoptosis, altered antioxidants (Cu/Zn-SOD, Mn-SOD, GPx and NO) activity and increasing formation of PCO. NO_2 inhalation also induced augment of oncogenes (c-fos,c-jun) levels, and deregulation of apoptosis-related genes (p53, bax and bcl-2) expression. With all above data, the present report provided essential information for the characterization of the neurotoxic hazard of NO_2 and related mechanisms, which is required in response to the general concern about the vulnerability of the neurological system to it.
机译:NO_2是一种众所周知的室内和室外污染物,可能会导致不良的健康问题。近来,积累但极其有限的证据表明,NO_2可能表达神经毒性,并引起多种神经系统疾病。在本研究中,在反复吸入不同浓度(5,10和20mg / m〜3)的大鼠皮层中,确定了NO_2的神经系统危害及其可能的机制。暴露7天(6小时/天)后,引起明显的不良反应,包括脑与体重的比例降低,脑部轻度病理,神经元凋亡增加,抗氧化剂改变(铜/锌超氧化物歧化酶,锰超氧化物歧化酶,GPx和NO )活性并增加PCO的形成。吸入NO_2也会诱导癌基因(c-fos,c-jun)水平升高,并导致细胞凋亡相关基因(p53,bax和bcl-2)的表达失控。利用上述所有数据,本报告为表征NO_2的神经毒性危害及相关机理提供了必要的信息,这是对神经系统易受伤害性的普遍关注所必需的。

著录项

  • 来源
    《Journal of Hazardous Materials》 |2012年第30期|p.46-53|共8页
  • 作者单位

    College of Environment and Resource, Center of Environmental Science and Engineering, Shanxi University, Taiyuan, Shanxi 030006, PR China;

    College of Environment and Resource, Center of Environmental Science and Engineering, Shanxi University, Taiyuan, Shanxi 030006, PR China;

    College of Environment and Resource, Center of Environmental Science and Engineering, Shanxi University, Taiyuan, Shanxi 030006, PR China;

    College of Environment and Resource, Center of Environmental Science and Engineering, Shanxi University, Taiyuan, Shanxi 030006, PR China;

    College of Environment and Resource, Center of Environmental Science and Engineering, Shanxi University, Taiyuan, Shanxi 030006, PR China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    nitrogen dioxide (NO_2); pallium; oncogenes; apoptosis-related genes;

    机译:二氧化氮(NO_2);钯癌基因凋亡相关基因;

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