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Evidence-informed evidence-making

机译：循证证据制作

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The extent to which clinical and public health guidance developed by the National Institute for Health and Clinical Excellence (NICE) can effectively serve the public by improving quality and efficiency across the National Health Service (NHS) and the broader public sector depends largely on the quality and relevance of the available evidence which informs its decisions. There are well-established organizational and procedural links between NICE and academic and professional organizations that undertake evidence synthesis. However, there are fewer means for evidence gaps identified during the development of NICE guidance to lead to the commissioning of new prospective studies. In this paper, we discuss the importance of a publicly funded clinical and public health research agenda that includes new prospective studies aimed at addressing knowledge gaps identified by NICE. We describe the early experience of NICE and the National Institute for Health Research (NIHR) working together to articulate and commission research to inform best practice recommendations. We propose ways in which NICE can collaborate more effectively with research funders to improve the evidence base upon which it bases its recommendations.
机译：美国国家卫生与临床卓越研究所（NICE）制定的临床和公共卫生指南在多大程度上可以通过提高国家卫生局（NHS）和更广泛的公共部门的质量和效率来有效地服务于公众以及可用于决策的可用证据的相关性。 NICE与进行证据综合的学术和专业组织之间已经建立了良好的组织和程序联系。但是，在NICE指南的制定过程中，发现导致新的前瞻性研究的证据空白的手段很少。在本文中，我们讨论了由公共资助的临床和公共卫生研究议程的重要性，其中包括旨在解决NICE识别的知识空白的新的前瞻性研究。我们描述了NICE和美国国立卫生研究院（NIHR）一起努力阐明和委托研究以提供最佳实践建议的早期经验。我们提出了NICE可以与研究资助者更有效合作的方式，以改善其推荐依据的证据基础。

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