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首页> 外文期刊>Journal of Health Services Research & Policy >Using qualitative research methods to improve recruitment to randomized controlled trials: the Quartet study
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Using qualitative research methods to improve recruitment to randomized controlled trials: the Quartet study

机译：使用定性研究方法改善随机对照试验的招募：四方研究

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Objective: Randomized controlled trials (RCTs) are considered the optimum method for evaluating health care interventions, yet many fail to recruit sufficient participants in a timely manner. The ProtecT (Prostate testing for cancer and Treatment) study employed qualitative research methods as part of a complex intervention to improve recruitment to the RCT. The Quartet (Qualitative research to improve recruitment to trials) study was set up to evalute whether the ProtecT study's success in increasing randomization rates could be replicated in other trials experiencing recruitment difficulties. This paper reports on the issues that emerged from the attempts to apply qualitative research methods to improve recruitment rates in RCTs collaborating with the Quartet team. nnMethods: The methods used were: investigation of RCT documents; semi-structured interviews and focus groups with RCT staff; audio-recording of recruitment appointments; and individual and group feedback sessions for RCT staff. Data were analysed using content and thematic analysis. Results: Barriers arose when we attempted to establish collaborations with RCTs. Difficulties were encountered in securing the commitment of all relevant staff because of poor communication between lead investigators and other staff as well as RCT staff's concerns about having recruitment appointments audio-recorded. Recruitment processes were often more complex than anticipated. Governance procedures took considerable time and resources, limiting the time available for data collection and implementation of the intervention before recruitment closure. nnConclusion: Straightforward replication of the ProtecT complex intervention was more complicated than expected. However, the study has increased understanding of RCT recruitment and identified ways to overcome barriers to collaboration. Such research is more easily undertaken in the feasibility stage of an RCT, and greater success will be achieved if the research is integrated into the everyday conduct of RCTs.
机译：目的：随机对照试验（RCT）被认为是评估卫生保健干预措施的最佳方法，但是许多人未能及时招募足够的参与者。 ProtecT（用于癌症和治疗的前列腺测试）研究采用定性研究方法作为复杂干预措施的一部分，以改善对RCT的招募。设立四方研究（定性研究以改善试验招募）是为了评估ProtecT研究在提高随机率方面的成功是否可以在其他遇到招募困难的试验中复制。本文报告了与四方小组合作使用定性研究方法来提高RCT招聘率的尝试中出现的问题。 nn方法：使用的方法是：研究RCT文件；与RCT工作人员的半结构化访谈和焦点小组；录用招聘录音；以及针对RCT工作人员的个人和小组反馈会议。使用内容和主题分析对数据进行分析。结果：当我们尝试与RCT建立合作关系时，出现了障碍。由于首席调查员与其他工作人员之间的沟通不畅，以及RCT工作人员对录用录用通知的担忧，在确保所有相关工作人员的承诺方面遇到了困难。招聘过程通常比预期的要复杂。治理程序花费了大量时间和资源，限制了在招聘结束之前可用于数据收集和实施干预措施的时间。 nn结论：ProtecT复杂干预的直接复制比预期的要复杂。但是，该研究增加了对RCT招聘的了解，并确定了克服合作障碍的方法。在RCT的可行性阶段更容易进行此类研究，如果将研究整合到RCT的日常行为中，将会取得更大的成功。

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