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Uncertainty Analysis of the Core Body Temperature Under Thermal and Physical Stress Using a Three-Dimensional Whole Body Model

机译:使用三维全身模型对热和物理应力下核心体温的不确定性分析

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Heat stress experienced by firefighters is a common consequence of extreme firefighting activity. In order to avoid the adverse health conditions due to uncompensable heat stress, the prediction and monitoring of the thermal response of firefighters is critical. Tissue properties, among other parameters, are known to vary between individuals and influence the prediction of thermal response. Further, measurement of tissue properties of each firefighter is not practical. Therefore, in this study, we developed a whole body computational model to evaluate the effect of variability (uncertainty) in tissue parameters on the thermal response of a firefighter during firefighting. Modifications were made to an existing human whole body computational model, developed in our lab, for conducting transient thermal analysis for a firefighting scenario. In conjunction with nominal (baseline) tissue parameters obtained from literature, and physiologic conditions from a firefighting drill, the Pennes' bioheat and energy balance equations were solved to obtain the core body temperature of a firefighter. Subsequently, the uncertainty in core body temperature due to variability in the tissue parameters (input parameters), metabolic rate, specific heat, density, and thermal conductivity was computed using the sensitivity coefficient method. On comparing the individual effect of tissue parameters on the uncertainty in core body temperature, the metabolic rate had the highest contribution (within ±0.20°C) followed by specific heat (within ±0.10°C), density (within ±0.07°C), and finally thermal conductivity (within ±0.01 °C). A maximum overall uncertainty of ±0.23 °C in the core body temperature was observed due to the combined uncertainty in the tissue parameters. Thus, the model results can be used to effectively predict a realistic range of thermal response of the firefighters during firefighting or similar activities.
机译:消防人员承受的热压力是极端消防活动的普遍结果。为了避免由于不可补偿的热应力而造成的不利健康状况,对消防员的热响应进行预测和监控至关重要。已知组织参数以及其他参数会在个体之间变化并影响对热反应的预测。此外,测量每个消防员的组织特性是不实际的。因此,在这项研究中,我们开发了一个整体计算模型来评估组织参数的可变性(不确定性)对消防员在消防过程中热响应的影响。对在我们的实验室中开发的现有人体全身计算模型进行了修改,以进行消防场景的瞬态热分析。结合从文献中获得的标称(基准)组织参数和消防演习的生理条件,求解了Pennes的生物热和能量平衡方程,以获得消防员的核心体温。随后,使用敏感性系数方法计算了由于组织参数(输入参数),代谢率,比热,密度和导热系数的变化而导致的核心体温的不确定性。在比较组织参数对核心体温不确定性的个体影响时,代谢率的贡献最大(在±0.20°C之内),其次是比热(在±0.10°C之内),密度(在±0.07°C之内) ,最后是导热率(在±0.01°C以内)。由于组织参数的综合不确定性,观察到核心体温的最大总体不确定性为±0.23°C。因此,模型结果可用于有效预测消防员在消防或类似活动中的实际热响应范围。

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