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首页> 外文期刊>Journal of Heat Transfer >Treatment Efficacy for Validating MicroCT-Based Theoretical Simulation Approach in Magnetic Nanoparticle Hyperthermia for Cancer Treatment
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Treatment Efficacy for Validating MicroCT-Based Theoretical Simulation Approach in Magnetic Nanoparticle Hyperthermia for Cancer Treatment

机译：验证基于MicroCT的理论模拟方法在磁性纳米热疗治疗癌症中的治疗功效

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The objective is to validate a designed heating protocol in a previous study based on treatment efficacy of magnetic nanoparticle hyperthermia in prostate tumors. In vivo experiments have been performed to induce temperature elevations in implanted PC3 tumors injected with magnetic nanoparticles, following the same heating protocol designed in our previous microCT-based theoretical simulation. A tumor shrinkage study and histological analyses of tumor cell death are conducted after the heating. Tumor shrinkage is observed over a long period of 8 weeks. Histological analyses of the tumors after heating are used to evaluate whether irreversible thermal damage occurs in the entire tumor region. It has been shown that the designed 25 min heating (Arrhenius integral Ω≥4 in the entire tumor) on tumor tissue is effective to cause irreversible thermal damage to PC3 tumors, while reducing the heating time to 12min (Ω>1 in the entire tumor) results in an initial shrinkage, however, later tumor recurrence. The treated tumors with 25 min of heating disappear after only a few days. On the other hand, the tumors in the control group without heating show approximately an increase of more than 700% in volume over the 8-week observation period. In the undertreated group with 12 min of heating, its growth rate is smaller than that in the control group. In addition, results of the histological analysis suggest vast regions of apoptotic and necrotic cells, consistent with the regions of significant temperature elevations. In conclusion, this study demonstrates the importance of imaging-based design for individualized treatment planning. The success of the designed heating protocol for completely damaging PC3 tumors validates the theoretical models used in planning heating treatment in magnetic nanoparticle hyperthermia.
机译：目的是在先前的研究中基于磁性纳米粒子热疗在前列腺肿瘤中的治疗功效来验证设计的加热方案。按照我们以前基于microCT的理论模拟中设计的相同加热方案，已经进行了体内实验，以诱导植入了磁性纳米粒子的PC3肿瘤的温度升高。加热后进行肿瘤缩小研究和肿瘤细胞死亡的组织学分析。在长达8周的时间内观察到肿瘤缩小。加热后对肿瘤的组织学分析用于评估整个肿瘤区域是否发生不可逆的热损伤。研究表明，在肿瘤组织上设计的25分钟加热（整个肿瘤中的Arrhenius积分Ω≥4）可有效地对PC3肿瘤造成不可逆的热损伤，同时将加热时间减少到12min（整个肿瘤中Ω> 1） ）导致最初的缩小，但是随后肿瘤复发。加热25分钟的治疗肿瘤仅在几天后消失。另一方面，在不加热的对照组中，在8周的观察期内，肿瘤的体积大约增加了700％以上。在加热不足12分钟的治疗不足的组中，其生长速率小于对照组。另外，组织学分析结果表明，凋亡和坏死细胞的区域很大，与温度明显升高的区域一致。总之，本研究证明了基于影像的设计对于个性化治疗计划的重要性。用于完全破坏PC3肿瘤的设计加热方案的成功验证了用于计划磁性纳米粒子热疗中加热治疗的理论模型。

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