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Assessment of Thermal Damage During Skin Tumor Treatment Using Thermal Wave Model: A Realistic Approach

机译：使用热波模型评估皮肤肿瘤治疗过程中的热损伤：一种现实的方法

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摘要

In this study, a three-layered skin tissue has been modeled to assess the heat transfer characteristics in laser skin tumor-tissue interaction. A finite-volume-based two-dimensional numerical bioheat transfer model has been put together to study the damage prediction of healthy tissues by considering both Fourier and non-Fourier laws. The combination of the bioheat transfer equation with Fourier law forms the parabolic equation (Pennes model) and with the non-Fourier equation forms the hyperbolic equation (ther-mal wave model). In this paper, the laser source is provided on the outer layer of the skin to dismantle the undesired tumor region exemplified as inhomogeneity (tumor) present in the intermediate layer. Heat input through the laser source is on until it reaches the tumor-killing criteria. The heat transport equation has been discretized by the finite volume method (FVM). The finite-volume-based numerical model is developed in such a way that the non-Fourier model predictions can be obtained through conventional Fourier-based solver. The central difference scheme is adopted for discretizing the spatial derivative terms. An implicit scheme is applied to treat the transient terms in the model. For few cases of the hyperbolic problems, certain limitation for a chosen implicit scheme has also been addressed in this paper. The results are validated with the existing literatures. The evaluated results are based on both the Fourier and the non-Fourier model, to investigate the temperature distribution and thermal damage by ensuring irreversible thermal damage in the whole tumor region placed in the dermis layer. Thermal damage of the healthy tissue is found to be more in the time scale of the thermal wave model.
机译：在这项研究中，已经对三层皮肤组织进行了建模，以评估激光皮肤肿瘤与组织相互作用中的传热特性。基于傅立叶和非傅立叶定律，基于有限体积的二维数值生物传热模型已被整合在一起，以研究健康组织的损伤预测。生物传热方程与傅立叶定律的组合形成抛物线方程（Pennes模型），与非傅立叶方程的组合构成双曲方程（热波模型）。在本文中，激光源设置在皮肤的外层上，以拆除不希望的肿瘤区域，例如存在于中间层中的不均匀性（肿瘤）。通过激光源的热量输入一直打开，直到达到杀死肿瘤的标准。传热方程已通过有限体积法（FVM）离散化。基于有限体积的数值模型的开发方式使得可以通过常规的基于傅立叶的求解器获得非傅立叶模型的预测。采用中心差分方案来离散空间导数项。应用隐式方案来处理模型中的瞬态项。对于双曲线问题的少数情况，本文还解决了对所选隐式方案的某些限制。结果得到了现有文献的验证。评估结果基于傅立叶模型和非傅立叶模型，通过确保放置在真皮层中整个肿瘤区域的不可逆热损伤来研究温度分布和热损伤。发现健康组织的热损伤在热波模型的时间尺度上更大。

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  • 来源
    《Journal of Heat Transfer》 |2017年第5期|051102.1-051102.9|共9页
  • 作者

    A.K.Verma; P.Rath; S.K.Mahapatra;

  • 作者单位

    School of Mechanical Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar 752050, India;

    School of Mechanical Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar 752050, India;

    School of Mechanical Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar 752050, India;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    skin tissue; tumor; bioheat transfer; non-Fourier;

    机译：皮肤组织;肿瘤;生物热传递;非傅立叶;

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