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首页> 外文期刊>Journal of Heat Transfer >Simulation of Phase Transition During Cryosurgical Treatment of a Tumor Tissue Loaded With Nanoparticles Using Meshfree Approach
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Simulation of Phase Transition During Cryosurgical Treatment of a Tumor Tissue Loaded With Nanoparticles Using Meshfree Approach

机译：使用无网格方法模拟冷冻治疗纳米粒子负载的肿瘤组织的相变

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摘要

In medical world, the minimally invasive freezing therapy or cryosurgery is an efficacious treatment for complete and controlled eradication of tumor cells. Many difficulties are encountered in cryosurgery process such as inappropriate freezing may not completely destroy the target tumor tissue and excessive freezing may harm the surrounding healthy tissues due to release of high amount of cold from the freezing probe. In present study, the target tumor tissue is loaded with nanoparticles in order to improve the freezing capacity of probe and to regulate the orientation and size of ice-ball formed during cryosurgery. In this process, phase transformation occurs in the undesired tumor tissues. For simulation of phase transition in bio heat transfer equation, the fixed-domain, heat capacity method is used to take into account the latent heat of phase change. In this study, a meshfree numerical technique known as element free Galerkin method (EFGM) is employed to simulate the phase transition and temperature field for a biological tissue subjected to nanocryosurgery. The latest nanofluid model which includes the effects of particles size, concentration, and the interfacial layer at the particle/liquid interface is utilized and their impact on freezing process is investigated in detail.
机译：在医学世界中，微创冷冻疗法或冷冻手术是一种用于彻底且有控制地根除肿瘤细胞的有效疗法。在冷冻手术过程中会遇到许多困难，例如不适当的冷冻可能不会完全破坏目标肿瘤组织，而过度冷冻可能会由于从冷冻探针中释放出大量的冷而伤害周围的健康组织。在本研究中，目标肿瘤组织中装有纳米颗粒，以提高探针的冷冻能力并调节冷冻手术期间形成的冰球的方向和大小。在此过程中，相变发生在不需要的肿瘤组织中。为了模拟生物传热方程中的相变，使用固定域热容法考虑了相变潜热。在这项研究中，采用无网格数值技术，称为无元素伽勒金法（EFGM），以模拟经历了纳米冷冻手术的生物组织的相变和温度场。利用了最新的纳米流体模型，该模型包括颗粒大小，浓度和颗粒/液体界面处的界面层的影响，并详细研究了它们对冷冻过程的影响。

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