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首页> 外文期刊>Journal of Huazhong University of Science and Technology >A Case-control Study on High-risk Factors for Newborn Hearing Loss in Seven Cities of Shandong Province
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A Case-control Study on High-risk Factors for Newborn Hearing Loss in Seven Cities of Shandong Province

机译：山东省7城市新生儿听力损失高危因素的病例对照研究。

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摘要

To investigate the high-risk factors for newborn hearing loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to pass the universal newborn hearing screening (UNHS) were referred to Jinan Newborn Hearing Screening and Rehabilitation Center from 7 newborn hearing screening centers in seven cities of Shandong province. One-to-one pair-matched case-control method was employed for statistical analysis of the basic features of definitely identified cases. High-risk factors relating to the bilateral hearing loss were evaluated by univariate and multivariate Logistic regression analysis. Our results revealed that 721 transferred newborns who didn't pass the hearing screening received audiological and medical evaluation and 367 were confirmed to have hearing loss. Of them, 177 neonates with hearing loss who met the matching requirements were included in the study as subjects. Univariate analysis showed that high-risk factors related to hearing loss incuded age of father, education backgrounds of parents, parity, birth weight, gestational weeks, craniofacial deformity, history of receiving treatment in neonatal intensive care unit (NICU), neonatal disease, family history of otopathy and family history of congenital hearing loss. Multivariate Logistic regression analysis revealed that 4 independent risk factors were related to bilateral hearing loss, including parity (OR = 16.285, 95% CI 3.379-78.481), neonatal disease (OR = 34,968, 95% CI 2.720-449.534), family history of congenital hearing loss (OR = 69.488, 95% CI 4.417-1093.300) and birth weight (OR = 0.241, 95% CI 0.090-0.648). It is concluded that parity, neonatal disease and family history of hearing loss are the promoting factors of bilateral hearing loss in neonates and appropriate intervention measures should be taken to deal with the risk factors.
机译：为了调查新生儿听力损失的高风险因素并提供信息以防止听力损失的发生并延缓其发展，从2003年5月至2006年6月，对未通过通用新生儿听力筛查（UNHS）的新生儿进行了转诊。山东省七个城市的7个新生儿听力筛查中心的济南新生儿听力筛查和康复中心。采用一对一配对的病例对照方法对确定病例的基本特征进行统计分析。通过单因素和多因素Logistic回归分析评估与双侧听力损失有关的高风险因素。我们的结果表明，有721例未通过听力筛查的转移新生儿接受了听觉和医学评估，其中367例被确认患有听力损失。其中，符合条件的177名听力下降的新生儿被纳入研究对象。单因素分析表明，与听力损失有关的高危因素包括父亲的年龄，父母的受教育程度，均等，出生体重，孕周，颅面畸形，新生儿重症监护病房（NICU）的接受治疗史，新生儿疾病，家庭耳病史和先天性听力损失家族史。多元Logistic回归分析显示4个独立的危险因素与双侧听力损失有关，包括胎次（OR = 16.285，95％CI 3.379-78.481），新生儿疾病（OR = 34,968，95％CI 2.720-449.534），先天性听力损失（OR = 69.488，95％CI 4.417-1093.300）和出生体重（OR = 0.241，95％CI 0.090-0.648）。结论：胎龄，新生儿疾病和家族性听力损失是新生儿双侧听力丧失的促进因素，应采取适当的干预措施来应对危险因素。

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