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首页> 外文期刊>Journal of Huazhong University of Science and Technology >Favorable Effect of Local VEGF Gene Injection on Axonal Regeneration in the Rat Sciatic Nerve
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Favorable Effect of Local VEGF Gene Injection on Axonal Regeneration in the Rat Sciatic Nerve

机译：局部VEGF基因注射对大鼠坐骨神经轴突再生的有利作用

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This study is to investigate the effect of local phVEGF_(165) injection on sciatic nerve regeneration in the rats and to search for a new way in the further treatment of peripheral nerve injuries. Forty-five adult male Wistar rats received a neurotomy to bilateral sciatic nerves, which were subsequently reconnected with 10/0 epineurial nylon sutures. The injured segments was locally injected with normal saline (group A), or 25 μg of phVEGF_(165) (group B) or 50 μg phVEGF_(165) (group C). Nerve conduction and regeneration were evaluated in terms of the histological changes, weight of gastrocnemius muscles, electrophysiology and morphometric results. Our study demonstrated that rats of group C showed the best results in terms of nerve regeneration, followed by group B and group A. Our findings suggested that local injection of phVEGF165 can facilitate nerve regeneration and promote functional recovery in a dose-dependent manner.
机译：本研究旨在探讨局部phVEGF_（165）注射液对大鼠坐骨神经再生的影响，并寻求进一步治疗周围神经损伤的新方法。四十五只成年雄性Wistar大鼠接受了双侧坐骨神经的神经切开术，随后将其与10/0肾上腺尼龙缝合线重新连接。受伤的节段局部注射生理盐水（A组）或25μgphVEGF_（165）（B组）或50μgphVEGF_（165）（C组）。根据组织学变化，腓肠肌重量，电生理学和形态测量结果评估神经的传导和再生。我们的研究表明，C组大鼠在神经再生方面表现出最好的结果，其次是B组和A组。我们的发现表明，局部注射phVEGF165可以促进神经再生并以剂量依赖性方式促进功能恢复。

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