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首页> 外文期刊>Journal of Huazhong University of Science and Technology >Expression of TLR9 and Its mRNA in the Lesions of Lichen Planus
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Expression of TLR9 and Its mRNA in the Lesions of Lichen Planus

机译：TLR9及其mRNA在扁平苔藓病变中的表达。

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摘要

To investigate the role of toll-like receptor 9 (TLR9) in the pathogenesis of lichen planus, the expressions of TLR9 and its mRNA in the lesional skin of lichen planus were detected by immunohistochemical technique (SP) and RT-PCR. As control, normal skin of healthy volunteers was also tested. The immunohistochemical study showed that the expression of TLR9 in the lesional skin of lichen planus was significantly higher than that in the normal controls. The results of RT-PCR showed that both skin lesions and normal controls had TLR9 expression. In skin lesions, the expression level of TLR9 mRNA was 1.6075 ± 0.0930, which was significantly higher than that in normal controls (P < 0.001). These findings indicated that up-regulated expression of TLR9 and its mRNA might be involved in the pathogenesis of lichen planus.
机译：为了研究Toll样受体9（TLR9）在扁平苔藓发病中的作用，采用免疫组化SP法和RT-PCR技术检测扁平苔藓病变皮肤中TLR9及其mRNA的表达。作为对照，还测试了健康志愿者的正常皮肤。免疫组织化学研究表明，扁平苔藓病变皮肤中TLR9的表达明显高于正常对照组。 RT-PCR的结果表明皮肤损伤和正常对照均具有TLR9表达。在皮肤病变中，TLR9 mRNA的表达水平为1.6075±0.0930，明显高于正常对照组（P <0.001）。这些发现表明TLR9及其mRNA的表达上调可能与扁平苔藓的发病有关。

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