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首页> 外文期刊>Journal of Huazhong University of Science and Technology >Effects of Acute Mechanical Stretch on the Expression of Mechanosensitive Potassium Channel TREK-1 in Rat Left Ventricle
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Effects of Acute Mechanical Stretch on the Expression of Mechanosensitive Potassium Channel TREK-1 in Rat Left Ventricle

机译：急性机械拉伸对大鼠左心室机械敏感性钾通道TREK-1表达的影响

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摘要

To explore the role of mechanosensitive potassium channel TREK-1, Western blot analysis was used to investigate the expression changes of TREK-1 in left ventricle in acute mechanically stretched heart. Forty Wistar rats were randomly divided into 8 groups (n=5 in each group), subject to single Langendorff perfusion for 0, 30, 60, 120 min and acute mechanical stretch for 0, 30, 60, 120 min respectively. With Langendorff apparatus, an acute mechanically stretched heart model was established. There was no significant difference in the expression of TREK-1 among single Langendorff perfusion groups (P> 0.05). As compared to non-stretched Langendorff-perfused heart, only the expression of TREK-1 in acute mechanically stretched heart (120 min) was greatly increased (P< 0.05). This result suggested that some course of mechanical stretch could up-regulate the expression of TREK-1 in left ventricle. TREK-1 might play an important role in mechanoelectric feedback, so it could reduce the occurrence of arrhythmia that was induced by extra mechanical stretch.
机译：为了探讨机械敏感性钾通道TREK-1的作用，采用蛋白质印迹分析来研究TREK-1在急性机械性拉伸心脏左心室中的表达变化。将40只Wistar大鼠随机分为8组（每组n = 5），分别进行一次Langendorff灌注0、30、60、120分钟和急性机械拉伸0、30、60、120分钟。使用Langendorff仪器，建立了急性机械拉伸心脏模型。在单个Langendorff灌注组之间，TREK-1的表达没有显着差异（P> 0.05）。与未拉伸的Langendorff灌注心脏相比，急性机械拉伸心脏（120分钟）仅TREK-1的表达大大增加（P <0.05）。该结果表明机械拉伸的某些过程可以上调TREK-1在左心室中的表达。 TREK-1在机电反馈中可能起重要作用，因此它可以减少因过度机械拉伸而引起的心律不齐的发生。

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