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首页> 外文期刊>Journal of the Institute of Brewing >Does Beer Contain Compounds That Might Interfere with Cholesterol Metabolism?
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Does Beer Contain Compounds That Might Interfere with Cholesterol Metabolism?

机译：啤酒中是否含有会干扰胆固醇代谢的化合物？

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摘要

Elevated blood cholesterol is a problem for many people. Although a significant proportion of this cholesterol arises from metabolism within the body, approximately 50% comes from our diet. Certain plant sterols (phytosterols) are known to inhibit the absorption of this dietary cholesterol by the human body, and there are now several commercially available food products that contain these phytosterols. Barley malt, yeast and hops also contain phytosterols or similar materials that might potentially act as inhibitors of cholesterol uptake but this effect has not been studied. In this work we examine one aspect of the potential for competition between cholesterol and selected beer components when binding to a protein. The method used was ligand docking. This uses computer modeling to examine the binding energies expected when the ligand (e.g. cholesterol or analogue) binds to a protein. The two proteins examined were both natural cholesterol binding proteins. The cholesterol analogues, sitosterol (from barley) and ergosterol (from yeast), had similar binding energies to cholesterol and thus had potential for competition. Other molecules (iso-xanthohumol, 8-prenylnaringenin (8PN) and iso-humulone) had lower binding energies suggesting that they would not compete effectively. Standard beers normally contain very low levels of either sitosterol or ergosterol, although some wheat beers that contain high levels of yeast may contain elevated levels of ergosterol. We have also developed a beer that contains elevated levels of sitosterol by incorporating whole grain material. The level of β-sitosterol in these beers was still very low and even a whole grain beer would not contain sufficient of the cholesterol analogues to completely inhibit cholesterol uptake or transport.
机译：胆固醇升高对许多人来说是一个问题。尽管这种胆固醇的很大一部分来自体内代谢，但大约50％来自我们的饮食。已知某些植物固醇（植物固醇）会抑制人体吸收这种饮食中的胆固醇，现在有几种含有这些植物固醇的可商购食品。大麦麦芽，酵母和啤酒花还含有植物甾醇或类似物质，可能会潜在地抑制胆固醇的摄取，但尚未对此效果进行研究。在这项工作中，我们研究了与蛋白质结合时胆固醇与某些啤酒成分之间竞争的潜力的一个方面。使用的方法是配体对接。当配体（例如胆固醇或类似物）与蛋白质结合时，这使用计算机建模来检查预期的结合能。检查的两种蛋白质均为天然胆固醇结合蛋白。胆固醇类似物谷固醇（来自大麦）和麦角甾醇（来自酵母）具有与胆固醇相似的结合能，因此具有竞争潜力。其他分子（异黄腐酚，8-异戊烯基柚皮素（8PN）和异hu草酮）的结合能较低，表明它们无法有效竞争。标准啤酒通常含有极少量的谷固醇或麦角固醇，尽管一些酵母含量较高的小麦啤酒可能含有升高的麦角固醇。我们还开发了一种通过掺入全谷物材料而提高谷固醇含量的啤酒。这些啤酒中的β-谷固醇含量仍然非常低，即使是全谷物啤酒也不会包含足够的胆固醇类似物以完全抑制胆固醇的摄取或转运。

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