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首页> 外文期刊>Journal of Liquid Chromatography & Related Technologies >SCREENING OF E- AND Z-GUGGULSTERONES IN THE GUM-RESIN EXUDATES OF SOME COMMON PLANTS AND METHOD VALIDATION IN RAW, EXTRACTED, AND PHARMACEUTICAL FORMULATIONS OF COMMIPHORA MUKUL BY HPLC
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SCREENING OF E- AND Z-GUGGULSTERONES IN THE GUM-RESIN EXUDATES OF SOME COMMON PLANTS AND METHOD VALIDATION IN RAW, EXTRACTED, AND PHARMACEUTICAL FORMULATIONS OF COMMIPHORA MUKUL BY HPLC

机译：HPLC对某些常见植物的胶状树脂分泌物中E-和Z-古格甾酮的筛选以及方法的验证

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摘要

Hypolipidemic agents, E- and Z-guggulsterones, are the biomarker compounds found in the gum-resin exudates of Commiphora mukul. Gum-Resin exudates of six common plants included Mangifera indica, Ficus religiosa, Delonix regia, Acacia nilotica, Abies balsamea, and Commiphora stocksiana and were screened against the said drug by the HPLC method. The developed method was validated for the quantification of E- and Z-guggulsterones in the gum-resin exudates of Commiphora mukul (raw form), guggulipid (ethyl acetate extract of gum-resin,) and its pharmaceutical products (finished form) that are the various components involved in the preparation of pharmaceutical products, from raw materials to finished products. The method involved a simple extraction procedure under sonication. The new method was validated as per the ICH recommended guidelines, including specificity, linearity, precision, accuracy, limit of quantitation, and robustness. The method has a validated quantitation range of 2-65 µg/mL with a precision of ±2% SD, recovery of 99.5% and correlation coefficients 0.999 for both E- and Z-guggulsterones. The statistical analysis proves that the method is repeatable and selective for the estimation of the said drugs and can be used as a routine analytical method and applicable to the different processing components involved in the pharmaceutical preparation from Commiphora mukul resin. Supplemental materials are available for this article. Go to the publisher's online edition of the Journal of Liquid Chromatograhy & Related Technologies to view the free supplemental file.View full textDownload full textKeywordsAbies balsamea and Commiphora stocksiana, Acacia nilotica, Commiphora mukul, Delonix regia, E- and Z-guggulsterones, Ficus religiosa, guggulipid, guggulu, HPLC analysis, Mangifera indicaRelated var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; Add to shortlist Link Permalink http://dx.doi.org/10.1080/10826076.2011.585481
机译：降血脂药E-和Z-古古甾酮是在Commiphora mukul的树胶树脂渗出物中发现的生物标志物化合物。六种常见植物的树胶-树脂渗出物包括印度芒果，榕属榕树，地龙，金合欢，苦瓜和香叶草，并通过HPLC方法针对所述药物进行筛选。所开发的方法经过验证可用于定量测定Commiphora mukul的树胶树脂渗出液（原始形式），guggulipid（树胶树脂的乙酸乙酯提取物）及其药物产品（成品形式）中的E-和Z-古格甾酮。从原材料到成品，药品制备中涉及的各个组成部分。该方法涉及在超声下的简单提取程序。该新方法已按照ICH推荐的指南进行了验证，包括特异性，线性，精密度，准确性，定量限和稳健性。该方法具有2-65 µg / mL的经过验证的定量范围，精度为±2％SD，回收率> 99.5％，E和Z-古古甾酮的相关系数> 0.999。统计分析证明，该方法对于所述药物的估计是可重复的和选择性的，并且可以用作常规分析方法，并且适用于来自印度mi树的药物制剂中涉及的不同加工组分。补充材料可用于本文。转到出版商的《液体色谱学报和相关技术杂志》的在线版本以查看免费的补充文件。查看全文下载全文关键词，古古皮，古古鲁，HPLC分析，印度芒果（Mangifera indica）相关var addthis_config = { ：“ ra-4dff56cd6bb1830b”};添加到候选列表链接永久链接http://dx.doi.org/10.1080/10826076.2011.585481

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