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首页> 外文期刊>Journal of Materials Engineering and Performance >Box-Behnken Design of Experiments Investigation of Hydroxyapatite Synthesis for Orthopedic Applications
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Box-Behnken Design of Experiments Investigation of Hydroxyapatite Synthesis for Orthopedic Applications

机译：用于骨科应用的羟基磷灰石合成实验研究的Box-Behnken设计

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摘要

Physicochemical properties of hydroxyapatite (HAp) synthesized by the chemical precipitation method are heavily dependent on the chosen process parameters. A Box-Behnken three-level experimental design was therefore, chosen to determine the optimum set of process parameters and their effect on various HAp characteristics. These effects were quantified using design of experiments (DoE) to develop mathematical models using the Box-Behnken design, in terms of the chemical precipitation process parameters. Findings from this research show that the HAp possessing optimum powder characteristics for orthopedic application via a thermal spray technique can therefore be prepared using the following chemical precipitation process parameters: reaction temperature 60 °C, ripening time 48 h, and stirring speed 1500 rpm using high reagent concentrations. Ripening time and stirring speed significantly affected the final phase purity for the experimental conditions of the Box-Behnken design. An increase in both the ripening time (36-48 h) and stirring speed (1200-1500 rpm) was found to result in an increase of phase purity from 47(±2)% to 85(±2)%. Crystallinity, crystallite size, lattice parameters, and mean particle size were also optimized within the research to find desired settings to achieve results suitable for FDA regulations.
机译：通过化学沉淀法合成的羟基磷灰石（HAp）的理化性质在很大程度上取决于所选的工艺参数。因此，选择了Box-Behnken三级实验设计来确定最佳的工艺参数集及其对各种HAp特性的影响。根据化学沉淀过程参数，使用实验设计（DoE）量化这些影响，以使用Box-Behnken设计开发数学模型。这项研究的发现表明，可以通过以下化学沉淀工艺参数制备具有通过热喷涂技术应用于骨科应用的最佳粉末特性的HAp：反应温度60°C，熟化时间48 h，搅拌速度1500 rpm（高试剂浓度。在Box-Behnken设计的实验条件下，成熟时间和搅拌速度会显着影响最终相的纯度。发现增加熟化时间（36-48小时）和搅拌速度（1200-1500 rpm）都会导致相纯度从47（±2）％增加到85（±2）％。在研究中还优化了结晶度，微晶尺寸，晶格参数和平均粒径，以找到所需的设置，以实现适合FDA法规的结果。

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