In vitro and in vivo biocompatibility of polyurethanes synthesized with castor oil polyols for biomedical devices

Uscategui Yomaira L.; Diaz Luis E.; Valero Manuel F.

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In vitro and in vivo biocompatibility of polyurethanes synthesized with castor oil polyols for biomedical devices

机译：与蓖麻油多元醇合成的聚氨酯在生物医学装置中的体外和体内生物相容性

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Polyurethanes (PUs) were synthesized with polyols derived from castor oil and isophorone diisocyanate. The materials were evaluated for their mechanical properties using stress-strain curves, thermogravimetric analysis, differential scanning calorimetry, and contact angle analysis. The biological response of the materials was evaluated by determining their cell viability in vitro, antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa, and biological response in vivo of PUs by means of implanting them in Wistar rats. The cell proliferation on the materials was analyzed using mouse fibroblast L929, human fibroblast MRC-5, and adult human dermal fibroblast (HDFa) cells by the ISO 10993-5 method. The materials showed no toxic effects and promoted cell proliferation. Experiments performed in vivo for 30 days in mice showed that the materials neither affected the wound healing process nor caused adverse effects or severe injuries in the dorsal mid-cervical tissue or organs on histological evaluation. PUs synthesized can be used in biomedical devices.

机译：聚氨酯（PU）与衍生自蓖麻油和异佛尔酮二异氰酸酯的多元醇合成。使用应力-应变曲线，热重分析，差示扫描量热法和接触角分析评估了材料的机械性能。通过确定它们的体外细胞存活力，对大肠杆菌和铜绿假单胞菌的抗菌活性以及通过将其植入Wistar大鼠体内的PU的体内生物响应，来评估它们的生物响应。通过ISO 10993-5方法，使用小鼠成纤维细胞L929，人成纤维细胞MRC-5和成年人真皮成纤维细胞（HDFa）分析了材料上的细胞增殖。该材料没有毒性作用，并能促进细胞增殖。在小鼠体内进行了30天的体内实验表明，根据组织学评估，该材料既不影响伤口愈合过程，也不会对背中子宫颈组织或器官造成不良影响或严重伤害。合成的PU可用于生物医学设备。

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来源
《Journal of Materials Research》 |2019年第4期|519-531|共13页
作者
Uscategui Yomaira L.; Diaz Luis E.; Valero Manuel F.;
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作者单位

Univ La Sabana, Res Grp Energy Mat & Environm, Doctoral Program Biosci, Chia 53753, Cundinamarca, Colombia;

Univ La Sabana, Res Grp Bioprospecting, Chia 53753, Cundinamarca, Colombia;

Univ La Sabana, Res Grp Energy Mat & Environm, Chem Engn Program, Chia 53753, Cundinamarca, Colombia;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
polyurethane; biomaterial; in vitro assay; in vivo assay;

机译：聚氨酯;生物材料;体外测定;体内测定;

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1. Antibacterial activity, hydrolytic and microbial degradation and in vitro cytotoxicity of polyurethane synthesized with polyols from castor oil derivatives [J] . Uscategui Yomaira L., Díaz Luis E., Valero Manuel F., Quimica nova . 2017,第2期

机译：蓖麻油衍生物多元醇合成的聚氨酯的抗菌活性，水解和微生物降解及体外细胞毒性
2. Characterization and in vitro biocompatibility of binary mixtures of chitosan and polyurethanes synthesized from chemically modified castor oil, as materials for medical use [J] . Fabián R. Arévalo, Sonia A. Osorio, Nathaly A. Valcárcel, Polymers from Renewable Resources . 2018,第1期

机译：用化学改性蓖麻油合成的壳聚糖和聚氨酯二元混合物的表征和体外生物相容性，作为医学用途
3. Structure and properties of the polyurethane and polyurethane foam synthesized from castor oil polyols [J] . Uldis Stirna, Brigita Lazdirja, Dzintra Vilsone Journal of Cellular Plastics . 2012,第6期

机译：由蓖麻油多元醇合成的聚氨酯和聚氨酯泡沫的结构和性能
4. Synthesis and characterization of non-absorbable surgical sutures obtained from polyurethanes synthesized from polyols derived from castor oil, isophorone diisocyanate and poly(∈-caprolactone): physico-mechanical properties, degradability and in vitro cytotoxicity [C] . Manuel Valero, Yomaira Uscategui, Fabian Arevalo, World biomaterials congress . 2016

机译：由蓖麻油，异佛尔酮二异氰酸酯和聚（ε-己内酯）衍生的多元醇合成的聚氨酯制得的非吸收性手术缝合线的合成和表征：物理力学性能，降解性和体外细胞毒性
5. Biocompatibility of ocular biomedical devices [D] . Gooch, Nathan Williams 2013

机译：眼部生物医学设备的生物相容性
6. Bio-Based Polyurethane Foams with Castor Oil Based Multifunctional Polyols for Improved Compressive Properties [O] . Joo Hyung Lee, Seong Hun Kim, Kyung Wha Oh 2021

机译：基于生物的聚氨酯泡沫具有蓖麻油的多官能多元醇可改善压缩性能
7. Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan [O] . Yomaira L. Uscátegui, Said J. Arévalo-Alquichire, José A. Gómez-Tejedor, 2017

机译：基于聚氨酯的生物粘合，由源自蓖麻油（Ricinus Communis）和低浓度的壳聚糖浓度合成

In vitro and in vivo biocompatibility of polyurethanes synthesized with castor oil polyols for biomedical devices

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