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首页> 外文期刊>Journal of Materials Research >Chitosan/hollow silica sphere nanocomposites for wound healing application
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Chitosan/hollow silica sphere nanocomposites for wound healing application

机译：壳聚糖/空心二氧化硅球纳米复合材料在伤口愈合中的应用

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摘要

Chitosan is an important cationic biopolymer widely used in various biomedical applications such as wound care, drug delivery, biomaterial scaffolds, and tissue engineering. In this work, hollow silica sphere (HSS) nanoparticles with an average size of 400-450 nm (via TEM) were synthesized by sol-gel process and were epoxidized using epichlorohydrin. Then, chitosan was chemically bound to the epoxidized HSS to form a bionanocomposite, HSS-epoxy-CHI-X where X represents the percentage of chitosan in the sample. BET analysis showed that pure HSS has a specific surface area (Ass) of around 4.8 m(2)/g and adsorption average pore diameter of 10.18 nm. Bionanocomposites were characterized by FT-IR spectroscopy to confirm the bonding of chitosan on HSS nanoparticles. X-ray diffraction studies demonstrated that the amorphous character of the materials improved with the HSS content. Thermogravimetric analysis illustrated that at low temperatures, the thermal stability of bionanocomposites was higher than that of the sample with no chitosan in it. Scanning electron microscopic analysis results confirmed the homogenous distribution of HSS in the bionanocomposites. Considering the biological activity of chitosan and absorption characteristics of HSS, newly developed HSS-epoxy-CHI-X bionanocomposites were tested for wound healing by in vitro scratch assay using NIH 3T3 fibroblast cells. Among the bionanocomposites analyzed, HSS-epoxy-CHI-60 exhibited better performance where about 90% wound closure was observed for this sample after 21 h of exposure.
机译：壳聚糖是一种重要的阳离子生物聚合物，广泛用于各种生物医学应用中，例如伤口护理，药物输送，生物材料支架和组织工程。在这项工作中，通过溶胶-凝胶法合成了平均尺寸为400-450 nm（通过TEM）的空心二氧化硅球（HSS）纳米粒子，并使用环氧氯丙烷将其环氧化。然后，将脱乙酰壳多糖化学键合到环氧化的HSS上，形成仿生复合物HSS-epoxy-CHI-X，其中X代表样品中壳聚糖的百分比。 BET分析表明，纯HSS的比表面积（Ass）约为4.8 m（2）/ g，吸附平均孔径为10.18 nm。通过FT-IR光谱对Bionanocomposites进行表征，以确认壳聚糖在HSS纳米颗粒上的键合。 X射线衍射研究表明，HSS含量提高了材料的非晶性。热重分析表明，在低温下，生物纳米复合材料的热稳定性高于没有壳聚糖的样品的热稳定性。扫描电子显微镜分析结果证实了HSS在仿生复合物中的均匀分布。考虑到壳聚糖的生物活性和HSS的吸收特性，使用NIH 3T3成纤维细胞通过体外刮擦试验测试了新开发的HSS-环氧-CHI-X仿生复合物的伤口愈合情况。在所分析的生物纳米复合材料中，HSS-环氧-CHI-60表现出更好的性能，在暴露21小时后，该样品观察到约90％的伤口闭合。

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  • 来源
    《Journal of Materials Research》 |2019年第2期|231-239|共9页
  • 作者

    Aslan Ayse; Elanthikkal Silviya; Bozkurt Ayhan;

  • 作者单位

    Gebze Tech Univ, Dept Bioengn, TR-41400 Gebze, Kocaeli, Turkey;

    Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Nanomed, Deanship Sci Res, Dammam 31441, Saudi Arabia;

    Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Biophys, Dammam 31441, Saudi Arabia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomedical; composite; nanoscale; polymer; sol-gel;

    机译：生物医学;复合材料;纳米级;聚合物;溶胶凝胶;

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