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首页> 外文期刊>Journal of Materials Research >Study on cytotoxicity of polyethylene glycol and albumin bovine serum molecule-modified quantum dots prepared by hydrothermal method
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Study on cytotoxicity of polyethylene glycol and albumin bovine serum molecule-modified quantum dots prepared by hydrothermal method

机译：水热法制备聚乙二醇和白蛋白牛血清分子改性量子点的细胞毒性研究

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摘要

Fluorescent quantum dots (QDs) modified with polyethylene glycol (PEG) and albumin bovine serum (BSA) have profound application in the detection and treatment of hepatocellular carcinoma (HCC) cells. In the present study, the effects and mechanism of PEG and BSA modification on the cytotoxicity of QDs have been explored. It was found that the diameter of the as-prepared QDs, PEG@QDs, BSA@QDs is 3-5 nm, 4-5 nm, and 4-6 nm, respectively. With increase of the treatment time from 0 to 24 h, the HCC cell viability treated with QDs, PEG@QDs, and BSA@QDs obviously decreases, showing a certain time-dependent manner. When the concentration of several nanomaterials is increased from 10 to 90 nM, the cell viability decreases accordingly, exhibiting a certain concentration-dependent manner. Under the same concentration change conditions, the reactive oxygen species contents of cells treated by QDs, PEG@QDs, and BSA@QDs also rise from 7.9 × 10~3, 6.7 × 10~3, and 4.7 × 10~3 to 13.2 × 10~3, 14.3 × 10~3, and 12.3 × 10~3, respectively. In these processes, superoxide dismutase does not play a major role. This study provides strong foundation and useful guidance for QD applications in the diagnosis and treatment of HCC.
机译：用聚乙二醇（PEG）和白蛋白牛血清（BSA）改性的荧光量子点（QDS）在肝细胞癌（HCC）细胞的检测和治疗中具有深刻的应用。在本研究中，探讨了PEG和BSA改性对QDS细胞毒性的影响和机制。发现，分别的AS制备的QDS，PEG @ QDS，BSA @ QDS的直径分别为3-5nm，4-5nm和4-6nm。随着从0到24小时的治疗时间的增加，用QDS，PEG @ QD和BSA QDS处理的HCC细胞活力明显降低，显示出一定的时间依赖性方式。当几纳米材料的浓度从10至90nm增加时，细胞活力相应地降低，表现出一定的浓度依赖性方式。在相同的浓度变化条件下，由QDS，PEG @ QDS和BSA @QDS处理的电池的反应性氧物种含量也从7.9×10〜3，6.7×10〜3和4.7×10〜3至13.2× 10〜3,14.3×10〜3和12.3×10〜3分别。在这些过程中，超氧化物歧化酶不会起到重要作用。本研究为HCC诊断和治疗中的QD应用提供了强大的基础和有用的指导。

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  • 来源
    《Journal of Materials Research》 |2020年第9期|1135-1142|共8页
  • 作者

    Enlv Hong; Lumin Liu; Chen Li; Dan Shan; Hailong Cao; Baiqi Wang;

  • 作者单位

    Department of Occupational and Environmental Health School of Public Health Tianjin Medical University Tianjin 300070 China;

    Department of Occupational and Environmental Health School of Public Health Tianjin Medical University Tianjin 300070 China;

    Department of Occupational and Environmental Health School of Public Health Tianjin Medical University Tianjin 300070 China;

    Department of Occupational and Environmental Health School of Public Health Tianjin Medical University Tianjin 300070 China;

    Department of Gastroenterology and Hepatology General Hospital Tianjin Medical University Tianjin 300052 China;

    Department of Occupational and Environmental Health School of Public Health Tianjin Medical University Tianjin 300070 China Tianjin Institute of Digestive Disease Tianjin Key Laboratory of Environment Nutrition and Public Health Tianjin 300070 China National Demonstration Center for Experimental Preventive Medicine Education (Tianjin Medical University) Tianjin 300070 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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