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首页> 外文期刊>Journal of Materials Research >A strategy for imaging-guided cocktail cancer therapy using dual-colored polymeric drug carriers with amplified aggregation-induced emission behavior by donor-acceptor/Foerster resonance energy transfer adjustment
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A strategy for imaging-guided cocktail cancer therapy using dual-colored polymeric drug carriers with amplified aggregation-induced emission behavior by donor-acceptor/Foerster resonance energy transfer adjustment

机译：通过供体 - 受体/ Foerster谐振能量转移调整具有扩增的聚集诱导的发射行为的双色聚合物药物载体的成像引导鸡尾酒癌疗法的策略

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摘要

Nowadays, theranostics drug delivery systems (DDSs) with imaging and therapy bi-functions have been regarded as a future orientation for imaging-guided cancer therapy. To achieve high imaging quality, a donor-acceptor (D-A)/F6rster resonance energy transfer (FRET) bi-adjustment strategy is carried out for designing dual-colored DDSs with amplified aggregation-induced emission (AIE) behavior for imaging-guided cocktail cancer therapy in this study. In detail, four AlE-active conjugated polymers P-1 to P-4 are synthesized via the Suzuki reaction. Noteworthily, the D-A-type structure is applied in tuning the fluorescence color from orange (P-1) to far-red/near-infrared (P-2), while the intramolecular FRET process further enhanced the fluorescence signal for six times (P-3). Afterwards, P-3-based amphipathic polymer P-4 further acts as a drug carrier in preparing doxorubicin (Dox)- and curcumin (Cur)-loaded polymer dots (Pdots) (Dox-loaded Pdots as PDox and Cur-loaded Pdots as PCur). PDox + PCur DDS is successfully applied in imaging-guided cocktail cancer therapy to give obviously higher in vivo anticancer efficacy compared with single PDox or PCur. In addition, the drug-loaded Pdots also exhibit higher biocompatibility compared with free drugs. This work provides a novel D-A/FRET bi-adjustment strategy for developing high efficiency imaging-guided cocktail DDSs in cancer therapy.
机译：如今，具有成像和治疗双功能的治疗药物输送系统（DDSS）被认为是成像引导癌症治疗的未来取向。为了实现高成像质量，进行施主 - 受体（DA）/ F6RSTER共振能量转移（FRET）双调整策略，用于设计具有扩增的聚集诱导的发射（AIE）行为的双色DDS用于成像引导的鸡尾酒癌本研究的治疗。详细地，通过铃木反应合成了四个叠层活性缀合聚合物P-1至P-4。值得注意的是，DA型结构用于将荧光颜色从橙色（P-1）调整为远红色/近红外（P-2），而分子内的FRET过程进一步增强了六次荧光信号（P -3）。然后，基于p-3的两亲性聚合物P-4进一步用作制备多柔比蛋白（DOX） - 和姜黄素（CUR）加载的聚合物点（PDOTS）（作为PDOX加载PDOX和CUR加载的PDOTS的药物载体中的药物载体PCUR）。 PDOX + PCUR DDS成功应用于成像引导的鸡尾酒癌疗法，与单PDOX或PCUR相比，体内抗癌疗效明显较高。此外，与游离药物相比，载药PDOS也表现出更高的生物相容性。这项工作为开发癌症治疗中的高效成像引导鸡尾酒DDS提供了一种新的D-A / FRET双调整策略。

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  • 来源
    《Journal of Materials Research》 |2020年第24期|3286-3295|共10页
  • 作者

    Mengxia Hua; Yi Zhou; Ziyu Wang; Cheng Wang; Lu Wang; Hong Yuan; Daoben Hua;

  • 作者单位

    School of Mathematics and Statistics Nanyang Normal University Nanyang 473061 PR China;

    Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123 PR China State Key Laboratory of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) Soochow University Suzhou 215123 PR China;

    State Key Laboratory of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) Soochow University Suzhou 215123 PR China;

    College of Pharmaceutical Science Zhejiang University Hangzhou 310058 PR China;

    State Key Laboratory of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) Soochow University Suzhou 215123 PR China;

    School of Mathematics and Statistics Nanyang Normal University Nanyang 473061 PR China;

    Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123 PR China State Key Laboratory of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) Soochow University Suzhou 215123 PR China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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