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首页> 外文期刊>Journal of Materials Research >Multi-stimuli-responsive magnetic hydrogel based on Tragacanth gum as a de novo nanosystem for targeted chemo/hyperthermia treatment of cancer
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Multi-stimuli-responsive magnetic hydrogel based on Tragacanth gum as a de novo nanosystem for targeted chemo/hyperthermia treatment of cancer

机译：基于TragaCanth Gum的多刺激磁性水凝胶作为癌症靶向化疗/热疗治疗癌症的De Novo纳米系统

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摘要

A novel magnetic pH- and redox-responsive drug delivery system (DDS) based on natural Tragacanth gum (TG) was developed for targeted chemo/hyperthermia treatment of cancer. Firstly, acrylic acid (AA) monomer was grafted onto a maleic anhydride-functionalized TG macromonomer (MATGM) through a free radical copolymerization. Magnetic nanoparticles (MNPs) were synthesized through chemical co-precipitation, and subsequently were modified using (3-aminopropyl)triethoxysilane coupling agent. The magnetic stimuli-responsive hydrogel for targeted cancer therapy was synthesized by the incorporation of modified-MNPs and folic acid (FA), and simultaneous crosslinking of TG-g-PAA copolymer using cystamine (Cys) moiety. Doxorubicin hydrochloride (Dox) was loaded into the fabricated magnetic hydrogel (MH), and its release was studied under pH- and redox-triggered condition.The anti-cancer activity of the Dox-loaded DDS was examined against MCF7 cells through MTT assay by both chemotherapy and chemo/hyperthermia therapy approaches. It was revealed that the developed DDS has higher anti-cancer activity (~ 24%) owing to its"smart"and slow drug release behavior as well as synergic effect of hyperthermia therapy.
机译：基于天然曲折胶（TG）的新型磁性pH-和氧化还原响应药物输送系统（DDS）用于癌症的靶向化疗/热疗。首先，通过自由基共聚合移植到马来酸酐官能化TG大分子单体（MATGM）上的丙烯酸（AA）单体。通过化学共沉淀合成磁性纳米颗粒（MNP），随后使用（3-氨基丙基）三乙氧基硅烷偶联剂进行改性。通过掺入修饰-MNP和叶酸（FA）的掺入靶癌疗法的磁刺激响应水凝胶，并使用胱胺（Cys）部分同时交联Tg-G-Paa共聚物。将盐酸辛酸（DOX）加载到制造的磁性水凝胶（MH）中，并在pH-和氧化还原的情况下研究其释放。通过MTT测定检查DOX加载DDS的抗癌活性。通过MTT测定检查了MCF7细胞。化疗和化疗/热疗治疗方法。据透露，由于其“智能”和缓慢的药物释放行为以及高温治疗的协同作用，发育的DDS具有更高的抗癌活动（〜24％）。

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  • 来源
    《Journal of Materials Research》 |2021年第4期|858-869|共12页
  • 作者

    Rana Jahanban-Esfahlan; Khadijeh Soleimani; Hossein Derakhshankhah; Babak Haghshenas; Aram Rezaei; Bakhshali Massoumi; Amir Farnudiyan-Habibi; Hadi Samadian; Mehdi Jaymand;

  • 作者单位

    Department of Medical Biotechnology School of Advanced Medical Sciences Tabriz University of Medical Sciences Tabriz Iran;

    Nano Drug Delivery Research Center Health Technology Institute Kermanshah University of Medical Sciences Kermanshah Iran;

    Pharmaceutical Sciences Research Center Health Institute Kermanshah University of Medical Sciences Kermanshah Iran;

    Regenerative Medicine Research Center Health Technology Institute Kermanshah University of Medical Sciences Kermanshah Iran;

    Nano Drug Delivery Research Center Health Technology Institute Kermanshah University of Medical Sciences Kermanshah Iran;

    Department of Chemistry Payame Noor University Tehran Iran;

    Department of Pharmaceutical Biomaterials Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Medical Biomaterials Research Center Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran;

    Nano Drug Delivery Research Center Health Technology Institute Kermanshah University of Medical Sciences Kermanshah Iran;

    Nano Drug Delivery Research Center Health Technology Institute Kermanshah University of Medical Sciences Kermanshah Iran;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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