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首页> 外文期刊>Journal of Materials Research >In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ε-caprolactone) and polyethylenimine
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In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ε-caprolactone) and polyethylenimine

机译:聚(ε-己内酯)和聚乙烯亚胺组成的电纺纳米纤维支架的体外评估

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摘要

The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly(ε-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs).
机译:这项工作旨在探讨广泛使用的阳离子聚合物聚乙烯亚胺(PEI)对小直径聚(ε-己内酯)(PCL)血管移植物的影响。将PEI与PCL混合,然后电纺成纳米纤维血管支架。研究了PCL / PEI电纺纳米纤维的形态,润湿性,机械性能和生物活性。发现通过将支架中PEI的含量增加到5%,纤维直径从469.7±212.1减小到282.5±107.1 nm,水接触角从126.6±1.1°减小到27.6±3.9°,而杨氏模量从2.0±0.2 MPa增加到4.1±0.1 MPa,缝线保持强度从4.2±0.4增加到6.1±0.7 N,破裂压力从801.2±14.1增加到926.2±22.8 mmHg。体外评估表明,含有2%PEI的纳米纤维促进了人脐静脉内皮细胞(HUVEC)的附着和增殖。

著录项

  • 来源
    《Journal of Materials Research》 |2015年第11期|1808-1819|共12页
  • 作者单位

    The Key Laboratory of Polymer Processing Engineering of Ministry of Education, South China University of Technology, Guangzhou 510640, China and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Wisconsin 53715, USA;

    The Key Laboratory of Polymer Processing Engineering of Ministry of Education, South China University of Technology, Guangzhou 510640, China and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Wisconsin 53715, USA;

    Wisconsin Institute for Discovery, University of Wisconsin-Madison, Wisconsin 53715, USA and Department of Engineering Physics, University of Wisconsin-Madison, Wisconsin 53715, USA;

    Wisconsin Institute for Discovery, University of Wisconsin-Madison, Wisconsin 53715, USA and Department of Biomedical Engineering, University of Wisconsin-Madison, Wisconsin 53715, USA;

    Wisconsin Institute for Discovery, University of Wisconsin-Madison, Wisconsin 53715, USA and Department of Mechanical Engineering, University of Wisconsin-Madison, Wisconsin 53715, USA;

    The Key Laboratory of Polymer Processing Engineering of Ministry of Education, South China University of Technology, Guangzhou 510640, China;

    Wisconsin Institute for Discovery, University of Wisconsin-Madison, Wisconsin 53715, USA and Department of Mechanical Engineering, University of Wisconsin-Madison, Wisconsin 53715, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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  • 正文语种 eng
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