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Engineered 2D nanomaterials-protein interfaces for efficient sensors

机译：工程化的2D纳米材料-蛋白质界面可实现高效传感器

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摘要

This article features the importance of nanomaterial-protein interfaces, with a special interest on two-dimensional (2D) nanomaterials, for next generation sensors and electronics. Graphene, the first isolated and studied 2D nanomaterial, is taken as the material of most interest and then focused on its engineering by heteroatom doping. The success of graphene engineering for sensors widened the search for better and efficient biosensor platforms of other layered materials such as boron nitride and transition metal dichalcogenides. But functionalization of 2D backbones with biomolecules often ends up with the disruption of the biological activities due to various reasons. This has to be fundamentally studied and corrected for the clinical implementation of these materials based novel sensing platforms in point-of-care devices and micro-fluidic chips. At the end, importance of various 2D materials-biomolecule interfaces is discussed, and MoS_2 based label-free biosensor is highlighted. A method for the modification of MoS_2-biomolecule interaction via covalent functionalization of oxygen functionalities in MoS_2 is also proposed.
机译：本文重点介绍了纳米材料-蛋白质界面的重要性，尤其是二维（2D）纳米材料对下一代传感器和电子产品的关注。石墨烯是第一个被隔离和研究的2D纳米材料，被认为是最受关注的材料，然后集中于通过杂原子掺杂进行的工程设计。石墨烯在传感器领域的成功应用拓宽了对其他层状材料（例如氮化硼和过渡金属二卤化碳）更好，更高效的生物传感器平台的探索。但是，由于各种原因，带有生物分子的2D骨架功能化常常导致生物活性的破坏。对于在护理设备和微流控芯片中基于这些材料的新型感测平台的临床实施，必须从根本上进行研究和纠正。最后，讨论了各种2D材料-生物分子界面的重要性，并重点介绍了基于MoS_2的无标记生物传感器。还提出了通过氧官能团在MoS_2中进行共价官能化来修饰MoS_2-生物分子相互作用的方法。

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  • 来源
    《Journal of Materials Research》 |2015年第23期|3565-3574|共10页
  • 作者

    Kiran Kumar Tadi; Tharangattu N. Narayanan; Sivaram Arepalli; Kaustav Banerjee; Sowmya Viswanathan; Dorian Liepmann; Pulickel M. Ajayan; Venkatesan Renugopalakrishnan;

  • 作者单位

    TIFR-Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Hyderabad - 500 075 Telangana, India;

    TIFR-Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Hyderabad - 500 075 Telangana, India;

    Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77251-1892, USA;

    Department of Electrical and Computer Engineering, University of California, Santa Barbara, California 93106-9560, USA;

    Newton Wellesley Hospital, Newton, Massachusetts 02462, USA;

    Department of Bioengineering, University of California, Berkeley, California 94720-1762, USA;

    Department of Materials Science and Nanoengineering, Rice University, Houston, Texas 77005-1892, USA;

    Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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