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Evaluation of Ti implants coated with Ag-containing borate bioactive glass for simultaneous eradication of infection and fracture fixation in a rabbit tibial model0

机译:评估含钛硼酸盐生物活性玻璃涂层的钛植入物在兔胫骨模型中同时根除感染和骨折固定的效果0

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摘要

The ability of silver (Ag)-containing borate bioactive glass (BG) coatings to improve the biocompatibility and antibacterial properties of titanium (Ti) implants was investigated in vitro and in vivo in a rabbit tibial fracture model. Dense coatings of borate BG (thickness ≈ 20 μm) containing 0, 0.75, and 1.0 wt% Ag_2O were prepared by depositing a layer of particles on Ti plates, followed by sintering at 900 ℃. The as-prepared coatings had an adhesive strength of 10 ± 1 MPa, and when immersed in an aqueous phosphate (K_2HPO_4) solution, the coatings converted to hydroxyapatite, releasing Ag~+ ions continuously for over 4 wk. After implantation of BG-coated Ti constructs in a rabbit tibial fracture model and of methicillin-resistant Staphylococcus aureus-induced osteomyelitis, the BG coating doped with 1.0 wt% Ag_2O was most effective for the simultaneous eradication of the infection and fracture fixation. Implants coated with Ag-containing BG coatings could provide an approach for reducing implant-related bone infection.
机译:在兔胫骨骨折模型中,研究了含银(Ag)硼酸盐生物活性玻璃(BG)涂层改善钛(Ti)植入物的生物相容性和抗菌性能的能力。通过在Ti板上沉积一层颗粒,然后在900℃下烧结,制备出包含0、0.75和1.0 wt%Ag_2O的硼酸BG致密涂层(厚度≈20μm)。所制备的涂层具有10±1 MPa的粘合强度,当浸入磷酸盐水溶液(K_2HPO_4)中时,涂层转化为羟基磷灰石,连续4周以上连续释放Ag〜+离子。在兔胫骨骨折模型中植入BG涂层的Ti构建体和耐甲氧西林金黄色葡萄球菌引起的骨髓炎后,掺有1.0 wt%Ag_2O的BG涂层对于同时根除感染和骨折固定最有效。用含银的BG涂层涂覆的植入物可以提供一种减少植入物相关的骨感染的方法。

著录项

  • 来源
    《Journal of Materials Research》 |2012年第24期|3147-3156|共10页
  • 作者单位

    Department of Materials Science and Engineering, Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China;

    Department of Traumatology, Shanghai Ruijin Hospital, Jiaotong University, Shanghai 200025, China;

    Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Jiaotong University,Shanghai 200233, China;

    Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Jiaotong University,Shanghai 200233, China;

    Department of Materials Science and Engineering, Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China;

    Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China;

    Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China;

    Department of Research and Development, Trauson (China) Medical Instrument Co., Ltd., Jiangsu 213164, China;

    Department of Materials Science and Engineering, Center for Bone and Tissue Repair and Regeneration, Missouri University of Science and Technology, Missouri 65409-0340;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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  • 正文语种 eng
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