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首页> 外文期刊>Journal of Materials Research >Influence of tricalcium aluminate phase on in vitro biocompatibility and bioactivity of calcium aluminate bone cement
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Influence of tricalcium aluminate phase on in vitro biocompatibility and bioactivity of calcium aluminate bone cement

机译：铝酸三钙相对铝酸钙骨水泥体外生物相容性和生物活性的影响

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摘要

The influence of tricalcium aluminate (3CaO centre dot Al_2O_3) phase doping on in vitro biocompatibility and bioactivity of calcium aluminate (CaO centre dot Al_2O_3) based bone cement has been investigated. It is demonstrated that the presence of approximately 25 percent tricalcium aluminate in the bone cement remarkably improves the bioactivity, yet still retains desirable mechanical strength and biocompatibility. An intermediary compound layer such as Ca_3Al_2(OH)_(12) was formed on the surface of the doped sample onto which hydroxyapatite (HAp) began to form soon, after only 2 days of immersion in a simulated body fluid solution. This is about seven-fold acceleration in the HAp formation over undoped calcium aluminate cement on which it took approximately 15 days to nucleate the HAp phase. The depth of the HAp-containing layer after 60 days of soaking was as much as 85 (mu)m, about an order of magnitude more than the undoped calcium aluminate cement. The dramatically accelerated nucleation and growth of hydroxyapatite caused by the presence of tricalcium aluminate is attributed to the occurrence of intermediate layer materials such as Ca_3Al_2(OH)_(12), which most likely acts as the nuclei for HAp formation. This doped bone cement can be useful for injectable orthopedic applications, as the setting time for hardening has also been significantly reduced (by a factor of at least 4) to a practical regime of tens of minutes.
机译：研究了铝酸三钙（3CaO中心点Al_2O_3）相掺杂对铝酸钙（CaO中心点Al_2O_3）基骨水泥体外生物相容性和生物活性的影响。结果表明，骨水泥中大约25％的铝酸三钙的存在显着提高了生物活性，但仍保留了理想的机械强度和生物相容性。在浸入模拟体液中仅两天后，在掺杂样品的表面上很快形成了中间化合物层，例如Ca_3Al_2（OH）_（12），羟基磷灰石（HAp）开始在其上形成。与未掺杂的铝酸钙水泥相比，HAp的形成速度要快大约七倍，在其上成核了HAp相大约需要15天。浸泡60天后，含HAp的层的深度高达85μm，比未掺杂的铝酸钙水泥高约一个数量级。由铝酸三钙的存在引起的羟基磷灰石的显着加速的成核和生长归因于中间层材料（例如Ca_3Al_2（OH）_（12））的出现，该中间层材料最有可能充当HAp形成的核。这种掺杂的骨水泥可用于可注射的整形外科应用，因为硬化的凝固时间也已显着减少（至少减少了4倍）至数十分钟的实用状态。

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  • 来源
    《Journal of Materials Research》 |2004年第4期|p.1062-1067|共6页
  • 作者

    S. H. Oh; R. Finones; S. Jin;

  • 作者单位

    Materials Sciences and Engineering Program, Department of Mechanical Aerospace Engineering, University of California at San Diego, La Jolla, California, 92093;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;
  • 关键词

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