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首页> 外文期刊>Journal of materials science >Microwave-assisted combustion synthesis of silica-coated Eu:Gd_2O_3 nanoparticles for MRI and optical imaging of cancer cells
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Microwave-assisted combustion synthesis of silica-coated Eu:Gd_2O_3 nanoparticles for MRI and optical imaging of cancer cells

机译：二氧化硅包覆的Eu：Gd_2O_3纳米粒子的微波辅助燃烧合成，用于MRI和癌细胞的光学成像

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摘要

Development of contrast agent for imaging modalities is very much essential to identify the cancer cells at an early stage. Due to the advances in the field of nanotechnology, nanoparticle-based contrast agents are being developed with better imaging capabilities at minimum concentrations. When the paramagnetic gadolinium oxide (Gd2O3) nanoparticles are doped with the luminescent europium (Eu3+) ions, it results in superior magneto-optical properties. This property makes the nanoparticles suitable for MRI and optical dual modal cancer imaging. In this article, europium doped Gd2O3 (Eu:Gd2O3) nanoparticles were synthesized by microwave-assisted combustion method. Citric acid (C6H8O7) which is a biocompatible and less reactive fuel was used to prepare the Eu:Gd2O3 nanoparticles for the first time. Silica was coated over the Eu:Gd2O3 nanoparticles for improving the biocompatibility. X-ray diffraction studies reveal that after coating, the crystallinity was found to decrease. The synthesized nanoparticles have spherical morphology with the average diameter of 10nm. The presence of silica was observed in the Fourier transform infrared (FTIR) spectrum and transmission electron microscopy images. In the photoluminescence studies, the emission peak at 612nm confirms the presence of Eu3+ ions. Decay times of the uncoated and silica-coated samples were calculated to be 1.1 and 0.9ms respectively. The in vitro cytotoxicity analysis suggests that the silica-coated nanoparticles are slightly toxic up to the concentration of 200 mu g/mL. The magnetic measurement confirms the paramagnetic behaviour of the synthesized nanoparticles. The nanoparticles shows bright contrast images with the relaxivity value of 5.01/(mM)/s, suggest that the silica-coated nanoparticles have potential applications in MRI.
机译：用于成像方式的造影剂的开发对于早期识别癌细胞非常重要。由于纳米技术领域的进步，正在开发基于纳米粒子的造影剂，并在最小浓度下具有更好的成像能力。当顺磁性氧化g（Gd2O3）纳米粒子掺有发光的（（Eu3 +）离子时，会产生出众的磁光特性。该性质使得纳米颗粒适合于MRI和光学双模态癌症成像。本文采用微波辅助燃烧法合成了do掺杂的Gd2O3（Eu：Gd2O3）纳米粒子。具有生物相容性且反应性较低的燃料柠檬酸（C6H8O7）首次用于制备Eu：Gd2O3纳米粒子。二氧化硅被涂覆在Eu：Gd2O3纳米颗粒上，以提高生物相容性。 X射线衍射研究表明，涂覆后结晶度降低。合成的纳米粒子具有平均直径为10nm的球形形态。在傅立叶变换红外（FTIR）光谱和透射电子显微镜图像中观察到二氧化硅的存在。在光致发光研究中，在612nm处的发射峰确认了Eu3 +离子的存在。计算出未涂覆样品和二氧化硅涂覆样品的衰减时间分别为1.1ms和0.9ms。体外细胞毒性分析表明，二氧化硅涂层的纳米颗粒在200μg / mL的浓度下仍具有轻微毒性。磁性测量证实了合成纳米颗粒的顺磁性行为。纳米颗粒显示出鲜明的对比度图像，其弛豫度值为5.01 /（mM）/ s，表明二氧化硅涂层的纳米颗粒在MRI中具有潜在的应用。

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  • 来源
    《Journal of materials science》 |2019年第7期|6860-6867|共8页
  • 作者

    Gayathri T.; Kumar R. Arun; Dhilipkumaran S.; Jayasankar C. K.; Saravanan P.; Devanand B.;

  • 作者单位

    PSG Coll Technol, GRD Ctr Mat Res, Coimbatore 641004, Tamil Nadu, India|Sri Shakthi Inst Engn & Technol, Dept Biomed Engn, Coimbatore, Tamil Nadu, India;

    PSG Coll Technol, GRD Ctr Mat Res, Coimbatore 641004, Tamil Nadu, India|PSG Coll Technol, Dept Phys, Coimbatore, Tamil Nadu, India;

    Anna Univ, Dept Phys, Chennai, Tamil Nadu, India;

    Sri Venkateswara Univ, Dept Phys, Tirupati, Andhra Pradesh, India;

    Def Met Res Lab, Hyderabad, India;

    PSG Hosp, Dept Radiol & Imaging, Coimbatore, Tamil Nadu, India;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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