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首页> 外文期刊>Journal of materials science >Simvastatin and zinc synergistically enhance osteoblasts activity and decrease the acute response of inflammatory cells
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Simvastatin and zinc synergistically enhance osteoblasts activity and decrease the acute response of inflammatory cells

机译：辛伐他汀和锌协同增强成骨细胞活性并减少炎症细胞的急性反应

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摘要

Several ceramic biomaterials have been suggested as promising alternatives to autologous bone to replace or restore bone after trauma or disease. The osteoinductive potential of most scaffolds is often rather low by themselves and for this reason growth factors or drugs have been supplemented to these synthetic materials. Although some growth factors show good osteoinductive potential their drawback is their high cost and potential severe side effects. In this work the combination of the well-known drug simvastatin (SVA) and the inorganic element Zinc (Zn) is suggested as a potential additive to bone grafts in order to increase their bone regeneration/ formation. MC3T3-E1 cells were cultured with Zn (10 and 25 mu M) and SVA (0.25 and 0.4 mu M) for 10 days to evaluate proliferation and differentiation, and for 22 days to evaluate secretion of calcium deposits. The combination of Zn (10 mu M) and SVA (0.25 mu M) significantly enhanced cell differentiation and mineralization in a synergetic manner. In addition, the release of reactive oxygen species (ROS) from primary human monocytes in contact with the same concentrations of Zn and SVA was evaluated by chemiluminescence. The combination of the additives decreased the release of ROS, although Zn and SVA separately caused opposite effects. This work shows that a new combination of additives can be used to increase the osteoinductive capacity of porous bioceramics.
机译：已经提出了几种陶瓷生物材料作为自体骨有希望的替代物，以在创伤或疾病后替代或修复骨。大多数支架自身的骨诱导潜力通常很低，因此，已经向这些合成材料补充了生长因子或药物。尽管某些生长因子显示出良好的骨诱导潜力，但其缺点是成本高和潜在的严重副作用。在这项工作中，建议将众所周知的药物辛伐他汀（SVA）和无机元素锌（Zn）组合作为骨移植物的潜在添加剂，以增加其骨再生/形成。将MC3T3-E1细胞与Zn（10和25μM）和SVA（0.25和0.4μM）培养10天以评估增殖和分化，并培养22天以评估钙沉积物的分泌。 Zn（10μM）和SVA（0.25μM）的组合以协同作用显着增强了细胞分化和矿化作用。另外，通过化学发光评估了与相同浓度的Zn和SVA接触的人类原代单核细胞释放的活性氧（ROS）。添加剂的组合降低了ROS的释放，尽管Zn和SVA分别引起相反的作用。这项工作表明，添加剂的新组合可用于提高多孔生物陶瓷的骨诱导能力。

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  • 来源
    《Journal of materials science》 |2016年第2期|23.1-23.9|共9页
  • 作者

    Montazerolghaem Maryam; Ning Yi; Engqvist Hakan; Ott Marjam Karlsson; Tenje Maria; Mestres Gemma;

  • 作者单位

    Uppsala Univ, Dept Engn Sci, Uppsala, Sweden;

    Uppsala Univ, Dept Engn Sci, Uppsala, Sweden;

    Uppsala Univ, Dept Engn Sci, Uppsala, Sweden;

    Uppsala Univ, Dept Engn Sci, Uppsala, Sweden|Sci Life Lab, Uppsala, Sweden;

    Uppsala Univ, Dept Engn Sci, Uppsala, Sweden|Sci Life Lab, Uppsala, Sweden|Lund Univ, Dept Biomed Engn, Lund, Sweden;

    Uppsala Univ, Dept Engn Sci, Uppsala, Sweden;

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