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首页> 外文期刊>Journal of materials science >Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves
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Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves

机译：人造心脏瓣膜中苯乙烯嵌段共聚物的血液相容性

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摘要

Certain styrenic thermoplastic block copolymer elastomers can be processed to exhibit anisotropic mechanical properties which may be desirable for imitating biological tissues. The ex-vivo hemocompatibility of four triblock (hard-soft-hard) copolymers with polystyrene hard blocks and polyethylene, polypropylene, polyisoprene, polybutadiene or polyisobutylene soft blocks are tested using the modified Chandler loop method using fresh human blood and direct contact cell proliferation of fibroblasts upon the materials. The hemocompatibility and durability performance of a heparin coating is also evaluated. Measures of platelet and coagulation cascade activation indicate that the test materials are superior to polyester but inferior to expanded polytetrafluoroethylene and bovine pericardium reference materials. Against inflammatory measures the test materials are superior to polyester and bovine pericardium. The addition of a heparin coating results in reduced protein adsorption and ex-vivo hemocompatibility performance superior to all reference materials, in all measures. The tested styrenic thermoplastic block copolymers demonstrate adequate performance for blood contacting applications.
机译：可以将某些苯乙烯类热塑性嵌段共聚物弹性体加工成具有各向异性的机械性能，这对于模仿生物组织可能是理想的。使用改良的钱德勒环法（Chandler loop method），使用新鲜人血和直接接触细胞增殖的改良Chandler环法，测试了四种三嵌段（硬-软-硬）共聚物与聚苯乙烯硬嵌段和聚乙烯，聚丙烯，聚异戊二烯，聚丁二烯或聚异丁烯软嵌段的体外血液相容性。成纤维细胞在材料上。还评估了肝素涂层的血液相容性和耐久性能。血小板和凝血级联活化的测量表明，测试材料优于聚酯，但次于膨胀的聚四氟乙烯和牛心包参考材料。抗炎措施测试材料优于聚酯和牛心包。在所有方面，添加肝素涂层可降低蛋白质吸附和离体血液相容性，优于所有参考材料。经测试的苯乙烯热塑性嵌段共聚物表现出足够的血液接触应用性能。

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  • 来源
    《Journal of materials science》 |2016年第2期|32.1-32.12|共12页
  • 作者

    Brubert Jacob; Krajewski Stefanie; Wendel Hans Peter; Nair Sukumaran; Stasiak Joanna; Moggridge Geoff D.;

  • 作者单位

    Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England;

    Univ Med Ctr Tuebingen, Dept Thorac & Cardiovasc Surg, Tubingen, Germany;

    Univ Med Ctr Tuebingen, Dept Thorac & Cardiovasc Surg, Tubingen, Germany;

    Freeman Rd Hosp, Cardiothorac Serv, Newcastle, NSW, Australia;

    Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England;

    Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England;

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