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首页> 外文期刊>Journal of materials science >Property-based design: optimization and characterization of polyvinyl alcohol (PVA) hydrogel and PVA-matrix composite for artificial cornea
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Property-based design: optimization and characterization of polyvinyl alcohol (PVA) hydrogel and PVA-matrix composite for artificial cornea

机译：基于特性的设计：用于人工角膜的聚乙烯醇（PVA）水凝胶和PVA-基质复合材料的优化和表征

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摘要

Each approach for artificial cornea design is toward the same goal: to develop a material that best mimics the important properties of natural cornea. Accordingly, the selection and optimization of corneal substitute should be based on their physicochemical properties. In this study, three types of polyvinyl alcohol (PVA) hydrogels with different polymerization degree (PVA1799, PVA2499 and PVA2699) were prepared by freeze-thawing techniques. After characterization in terms of transparency, water content, water contact angle, mechanical property, root-mean-square roughness and protein adsorption behavior, the optimized PVA2499 hydrogel with similar properties of natural cornea was selected as a matrix material for artificial cornea. Based on this, a biomimetic artificial cornea was fabricated with core-and-skirt structure: a transparent PVA hydrogel core, surrounding by a ringed PVA-matrix composite skirt that composed of graphite, Fe-doped nano hydroxyapatite (n-Fe-HA) and PVA hydrogel. Different ratio of graphite-Fe-HA can tune the skirt color from dark brown to light brown, which well simulates the iris color of Oriental eyes. Moreover, morphologic and mechanical examination showed that an integrated core-and-skirt artificial cornea was formed from an interpenetrating polymer network, no phase separation appeared on the interface between the core and the skirt.
机译：每种人造角膜设计方法都朝着相同的目标：开发一种最能模仿天然角膜重要特性的材料。因此，角膜替代物的选择和优化应基于其理化性质。在本研究中，通过冻融技术制备了三种聚合度不同的聚乙烯醇（PVA）水凝胶（PVA1799，PVA2499和PVA2699）。在对透明度，水含量，水接触角，机械性能，均方根粗糙度和蛋白质吸附行为进行表征后，选择了具有与天然角膜相似性能的优化PVA2499水凝胶作为人造角膜的基质材料。在此基础上，制成了仿生的人造角膜，具有芯裙结构：透明的PVA水凝胶芯，周围是由石墨，Fe掺杂的纳米羟基磷灰石（n-Fe-HA）组成的环状PVA-矩阵复合裙和PVA水凝胶。石墨/ n-Fe-HA的不同比例可以将裙边颜色从深棕色变成浅棕色，从而很好地模拟了东方眼睛的虹膜颜色。此外，形态和力学检查表明，由互穿的聚合物网络形成了完整的纤芯裙缘人工角膜，纤芯与裙缘之间的界面上没有相分离。

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  • 来源
    《Journal of materials science》 |2014年第3期|941-952|共12页
  • 作者

    Hong Jiang; Yi Zuo; Li Zhang; Jidong Li; Aiming Zhang; Yubao Li; Xiaochao Yang;

  • 作者单位

    Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, People's Republic of China,Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, People's Republic of China;

    Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, People's Republic of China;

    Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, People's Republic of China;

    Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, People's Republic of China;

    Sinopec Sichuan Vinylon Factory, Chongqing 401254, People's Republic of China;

    Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, People's Republic of China;

    Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, People's Republic of China;

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