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首页> 外文期刊>Journal of materials science >Phase assemblage study and cytocompatibility property of heat treated potassium magnesium phosphate-silicate ceramics
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Phase assemblage study and cytocompatibility property of heat treated potassium magnesium phosphate-silicate ceramics

机译：热处理磷酸钾镁硅酸盐陶瓷的相组装研究和细胞相容性

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摘要

This article reports the study on a new generation bioactive ceramic, based on MgKPO_4 (Magnesium Potassium Phosphate, abbreviated as MKP) for biomedical applications. A series of heat treatment experiments on the slip cast silica (SiO_2) containing MKP ceramics were carried out at 900, 1,000 and 1,100℃ for 4 h in air. The density of the slip cast ceramic increases to 2.5 gm/cm~3 upon heat treatment at 900℃. However, no significant change in density is measured upon heat treatment to higher temperature of 1,000 and l,100℃. On the basis of XRD results, the presence of K_2MgSi_5O_(12) and dehydrated MgKPO_4 were confirmed and complementary information has also been obtained using FT-IR and Raman spectros-copy. In order to confirm the in vitro cytocompatibility property, the cell culture tests were carried out on selected samples and the results reveal good cell adhesion and spreading of L929 mouse fibroblast cells. MTT assay analysis with L929 cells confirmed non-cytotoxic behavior of MKP containing ceramics and the results are comparable with sintered HAp ceramics. It is expected that the newly developed MKP based materials could be a good substitute for hydroxyapatite (HAp or HA) based bioceramics.
机译：本文报道了基于MgKPO_4（磷酸镁钾，缩写为MKP）的新一代生物活性陶瓷的研究，该陶瓷用于生物医学应用。在空气中，分别在900、1,000和1,100℃下对含MKP陶瓷的滑模二氧化硅（SiO_2）进行了一系列热处理实验，时间为4 h。在900℃下进行热处理后，滑铸陶瓷的密度增加到2.5 gm / cm〜3。然而，热处理至1,000和1,100℃的较高温度后，密度没有显着变化。根据X射线衍射结果，证实了K_2MgSi_5O_（12）和脱水MgKPO_4的存在，并且使用FT-IR和拉曼光谱法也获得了补充信息。为了证实体外细胞相容性，对选定的样品进行了细胞培养试验，结果表明L929小鼠成纤维细胞具有良好的细胞粘附性和铺展性。用L929细胞进行的MTT分析证实了含MKP陶瓷的无细胞毒性，其结果与烧结HAp陶瓷相当。期望新开发的基于MKP的材料可以很好地替代基于羟基磷灰石（HAp或HA）的生物陶瓷。

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  • 来源
    《Journal of materials science》 |2009年第8期|1689-1695|共7页
  • 作者

    Ravi Kumar; Sushma Kalmodia; Shekhar Nath; Dileep Singh; Bikramjit Basu;

  • 作者单位

    Laboratory for Advanced Ceramics, Department Materials and Metallurgical Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India;

    Laboratory for Advanced Ceramics, Department Materials and Metallurgical Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India;

    Laboratory for Advanced Ceramics, Department Materials and Metallurgical Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India;

    Nuclear Engineering Division, Argonne National Laboratory, Argonne, IL, USA;

    Laboratory for Advanced Ceramics, Department Materials and Metallurgical Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India;

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