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Development of in situ-forming hydrogels for hemorrhage control

机译：用于出血控制的原位形成水凝胶的开发

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摘要

We report the preparation of in situ-forming hydrogels, composed of oxidized dextran (Odex) and amine-containing polymers, for their potential use as a wound dressing to promote blood clotting. Dextran was oxidized by sodium periodate to introduce aldehyde groups to form hydrogels, upon mixing in solution with different polymers containing primary amine groups, including polyallylamine (PAA), oligochitosan and glycol chitosan. A series of experiments were conducted to identify the optimum gelation condition for the Odex-PAA system. The polymer concentration appeared to have a major effect on gelation time and the polymer weight ratio affected the resulting gel content and swelling. Other influencing factors included pH of the buffer used to dissolve each polymer, PAA molecular weight, and the type of individual material. The latter also contributed significantly to gel content and swelling. Thromboelastog-raphy was used to examine the effects of the in situ gelation on blood coagulation in vitro, where the Odex-PAA combination was found to be most pro-hemostatic, as indicated by a decrease in clotting time and an increase in clot strength. The results of this study demonstrated that in situ-forming hydrogels could promote clotting in vitro; however, further studies are required to determine if the same hydrogel formulations are effective in controlling hemorrhage in vivo.
机译：我们报告了由氧化葡聚糖（Odex）和含胺聚合物组成的原位形成水凝胶的制备，其潜在用途可作为伤口敷料以促进血液凝结。将葡聚糖通过高碘酸钠氧化以引入醛基以形成水凝胶，然后在溶液中将其与包含伯胺基的不同聚合物（包括聚烯丙胺（PAA），低聚壳聚糖和乙二醇壳聚糖）混合。进行了一系列实验，以确定Odex-PAA系统的最佳凝胶化条件。聚合物浓度似乎对胶凝时间有主要影响，并且聚合物重量比影响所得的凝胶含量和溶胀。其他影响因素包括用于溶解每种聚合物的缓冲液的pH值，PAA分子量和单个材料的类型。后者也显着促进了凝胶含量和溶胀。血栓弹力图用于检查原位凝胶化对体外血液凝固的影响，其中发现Odex-PAA组合最具有止血作用，这可通过减少凝血时间和增加血凝强度来表明。这项研究的结果表明，原位形成的水凝胶可以促进体外凝结。然而，需要进一步的研究来确定相同的水凝胶制剂在体内控制出血方面是否有效。

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  • 来源
    《Journal of materials science》 |2009年第8期|1753-1762|共10页
  • 作者

    Henry T. Peng; Pang N. Shek;

  • 作者单位

    Defence Research and Development Canada - Toronto, 1133 Sheppard Avenue West, Toronto, ON M3M 3B9, Canada;

    Defence Research and Development Canada - Toronto, 1133 Sheppard Avenue West, Toronto, ON M3M 3B9, Canada;

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