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首页> 外文期刊>Journal of materials science >Formation of carbonated apatite particles from a supersaturated inorganic blood serum model
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Formation of carbonated apatite particles from a supersaturated inorganic blood serum model

机译：由过饱和无机血清模型形成碳酸磷灰石颗粒

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摘要

Pathological calcification is common among for instance dialysis patients, and this causes an increase in mortality risk. An elevated serum phosphate concentration among those patients strongly correlates to this increase. In this work investigations of the conditions, composition, crystallinity and morphology of in vitro calcification are performed and related to results from in vivo studies. The study was performed under conditions mimicking physiological ones, i.e. a pH around 7.40, a temperature of 37℃, an ionic strength of 150 mM and ion concentrations close to those in human serum including the effects of elevated phosphate concentrations. The course of precipitation involves an initial precipitate that subsequently re-dissolves to give another precipitate, in accordance with the well-known Ostwald ripening theory. The final bulk precipitate consists of a macro-scopically amorphous carbonated apatite. The amorphous apatite is formed from assemblies of spherical particles in the μm range, in turn composed of nano-crystalline needles of about 10 × 100 nm. Even the initially formed precipitate, as well as a small amount of precipitate that occurs on the liquid surface, consist of a carbonated calcium phosphate. The in vitro observed carbonatedrnapatite bears strong resemblance to in vivo cardiovascular calcification known from literature.
机译：病理性钙化在例如透析患者中​​是常见的，并且这导致死亡风险增加。这些患者中血清磷酸盐浓度的升高与这种增加密切相关。在这项工作中，进行了体外钙化的条件，组成，结晶度和形态的调查，并且与体内研究的结果有关。该研究是在模仿生理条件的条件下进行的，即pH值约为7.40，温度为37℃，离子强度为150 mM，并且离子浓度接近于人血清中的浓度，其中包括磷酸盐浓度升高的影响。根据众所周知的奥斯特瓦尔德（Ostwald）熟化理论，沉淀过程涉及初始沉淀，随后其重新溶解以产生另一种沉淀。最终的整体沉淀物由宏观无定形的碳酸磷灰石组成。非晶磷灰石由微米范围内的球形颗粒集合体形成，依次由约10×100 nm的纳米晶体针组成。甚至最初形成的沉淀以及在液体表面上出现的少量沉淀也由碳酸磷酸钙组成。体外观察到的碳酸盐/钠磷灰石与文献中已知的体内心血管钙化非常相似。

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  • 来源
    《Journal of materials science》 |2009年第8期|1677-1687|共11页
  • 作者

    Karin Sandin; Lars Kloo; Pernilla Nevsten; Reine L. Wallenberg; Lars-Fride Olsson;

  • 作者单位

    Gambro Corporate Research, Lund, Sweden Department of Chemistry, Royal Institute of Technology, Stockholm, Sweden;

    Department of Chemistry, Royal Institute of Technology, Stockholm, Sweden;

    nCHREM (National Center of High Resolution Electron Microscopy), Lund University, Lund, Sweden;

    nCHREM (National Center of High Resolution Electron Microscopy), Lund University, Lund, Sweden;

    Gambro Corporate Research, Lund, Sweden;

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