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首页> 外文期刊>Journal of Materials Science. Materials in Medicine >Osteointegration of poly(L-lactic acid)PLLA and poly(L-lactic acid)PLLA/poly(ethylene oxide)PEO implants in rat tibiae
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Osteointegration of poly(L-lactic acid)PLLA and poly(L-lactic acid)PLLA/poly(ethylene oxide)PEO implants in rat tibiae

机译：聚（L-乳酸）PLLA和聚（L-乳酸）PLLA /聚（环氧乙烷）PEO植入物在大鼠胫骨中的骨整合

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Natural or synthetic materials may be used to aid tissue repair of fracture or pathologies where there has been a loss of bone mass. Polymeric materials have been widely studied, aiming at their use in orthopaedics and aesthetic plastic surgery. Polymeric biodegradable blends formed from two or more kinds of polymers could present faster degradation rate than homopolymers. The purpose of this work was to compare the biological response of two biomaterials: poly(L-lactic acid)PLLA and poly(L-lactic acid)PLLA/poly(ethylene oxide)PEO blend. Forty four-week-old rats were divided into two groups of 20 animals, of which one group received PLLA and the other PLLA/ PEO implants. In each of the animals, one of the biomaterials was implanted in the proximal epiphysis of the right tibia. Each group was divided into subgroups of 5 animals, and sacrificed 2, 4, 8 and 16 weeks after surgery, respectively. Samples were then processed for analysis by light microscopy. Newly formed bone was found around both PLLA and PLLA/PEO implants. PLLA/PEO blends had a porous morphology after immersion in a buffer solution and in vivo implantation. The proportion 50/50 PLLA/PEO blend was adequate to promote this porous morphology, which resulted in gradual bone tissue growth into the implant.
机译：天然或合成材料可用于辅助骨质流失的骨折或病理组织的修复。高分子材料已被广泛研究，旨在用于整形外科和美学整形外科。由两种或更多种聚合物形成的可生物降解的聚合物共混物的降解速度要比均聚物快。这项工作的目的是比较两种生物材料的生物响应：聚（L-乳酸）PLLA和聚（L-乳酸）PLLA /聚（环氧乙烷）PEO共混物。将44只四周大的大鼠分为两组，每组20只，其中一组接受PLLA，另一组接受PLLA / PEO植入物。在每只动物中，一种生物材料被植入右胫骨的近端骨physi中。每组分成5只动物的亚组，并在手术后2、4、8和16周分别处死。然后对样品进行处理以通过光学显微镜分析。在PLLA和PLLA / PEO植入物周围都发现了新形成的骨头。将PLLA / PEO共混物浸入缓冲溶液中并进行体内植入后，具有多孔形态。 50/50 PLLA / PEO混合物的比例足以促进这种多孔形态，从而导致骨骼组织逐渐生长到植入物中。

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