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首页> 外文期刊>Journal of Materials Science >Preparation and properties of a novel thermo-responsive poly(N-isopropylacrylamide) hydrogel containing glycyrrhetinic acid
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Preparation and properties of a novel thermo-responsive poly(N-isopropylacrylamide) hydrogel containing glycyrrhetinic acid

机译：新型含甘草次酸热响应性聚（N-异丙基丙烯酰胺）水凝胶的制备及性能

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摘要

A novel thermo-responsive poly(N-isopropylacrylamide) (PNIPAAm) hydrogel containing glycyrrhetinic acid(GA) was synthesized by free radical copolymerization. The structure of the product was confirmed by FT-IR and 1H-NMR spectra. The temperature responsibility and swelling properties of the copolymerized hydrogel were investigated by differential scanning calorimetry (DSC) and gravimetric methods. The results indicated that GA-incorporated hydrogel was still temperature responsive and the swelling ratio decreased with the increasing of temperature. The lower critical solution temperature (LCST) of GA-incorporated hydrogel and poly(N-isopropylacrylamide) hydrogel was 30.00 °C and 31.21 °C, respectively, in distilled water. However, these two values were shifted to 28.22 °C and 29.16 °C in cell culture media. The novel hydrogel also exhibited reversible temperature responsibility. Deswelling kinetics indicated that the copolymerized hydrogel deswelled more rapidly than poly(N-isopropylacrylamide) hydrogel. Since GA has specific binding capacity to asialoglycoprotein receptors on the membrane of hepatocyte, this novel hydrogel with GA could be expected as good candidate for hepatic cell culture.
机译：通过自由基共聚反应，合成了一种新型的含甘草次酸（GA）的热敏性聚（N-异丙基丙烯酰胺）（PNIPAAm）水凝胶。产物的结构通过FT-IR和 1 H-NMR谱确认。通过差示扫描量热法（DSC）和重量分析法研究了共聚水凝胶的温度响应性和溶胀性能。结果表明，掺有GA的水凝胶仍对温度有响应，溶胀率随温度的升高而降低。掺有GA的水凝胶和聚（N-异丙基丙烯酰胺）水凝胶在蒸馏水中的最低临界溶液温度（LCST）分别为30.00°C和31.21°C。但是，在细胞培养基中，这两个值分别变为28.22°C和29.16°C。新型水凝胶还表现出可逆的温度响应性。溶胀动力学表明，共聚的水凝胶比聚（N-异丙基丙烯酰胺）水凝胶的溶胀更快。由于GA对肝细胞膜上的去唾液酸糖蛋白受体具有特定的结合能力，因此这种具有GA的新型水凝胶可望成为肝细胞培养的良好候选者。

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