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首页> 外文期刊>Journal of Medical Virology >Effect of an immunogenic complex containing WHV viral particles and non-neutralizing anti-HBs antibodies on the outcome of WHV infection in woodchucks†
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Effect of an immunogenic complex containing WHV viral particles and non-neutralizing anti-HBs antibodies on the outcome of WHV infection in woodchucks†

机译：包含WHV病毒颗粒和非中和性抗HBs抗体的免疫原性复合物对土拨鼠WHV感染结果的影响†

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摘要

The Eastern woodchuck (Marmota monax) is a useful experimental model for evaluating antiviral therapy against chronic HBV infection. In the present study, an immunogenic complex (IGC) composed of immune sera containing PreS/S heterologous antibodies (anti-HBs) and serum-derived WHV particles containing 107 WHV–DNA copies/50 µl was developed. The IGC was administered to WHV-negative woodchucks and natural chronic WHV carriers, with the final aim of evaluating the outcome of WHV infection in both groups. A control group of three animals, infected experimentally with viral particles only, was also evaluated. Following IGC administration, two WHV-negative woodchucks exhibited persistent infection, with WHV–DNA levels 3–6 logs lower than the WHV–DNA levels of the controls that developed persistent infection. WHeAg seroconversion to anti-WHe was observed in these two woodchucks and in two control woodchucks which developed self-limited infection. In two of the four chronic carriers, the WHV–DNA level decreased significantly (by 4–6 logs) following IGC administration, with no rebound in viral load during follow-up. WHeAg seroconversion to anti-WHe was observed also in these animals. Analyses of the sequences derived from envelope proteins confirmed that IGC did not induce the emergence of resistant viral variants. The results of this study indicate that the IGC could be useful for breaking the tolerance in hepadnaviral infection and for boosting the host's innate and adoptive immune response. J. Med. Virol. 83:178–186, 2011. © 2010 Wiley-Liss, Inc.
机译：东部土拨鼠（Marmota monax）是评估慢性HBV感染的抗病毒治疗的有用实验模型。在本研究中，开发了一种免疫原性复合物（IGC），该复合物由含有PreS / S异源抗体（抗HBs）的免疫血清和含有107 WHV-DNA拷贝/ 50 µl的血清来源WHV颗粒组成。 IGC用于WHV阴性的土拨鼠和自然的慢性WHV携带者，其最终目的是评估两组中WHV感染的结果。还评估了仅用实验方法感染病毒颗粒的三只动物的对照组。 IGC给药后，两只WHV阴性的土拨鼠表现出持续感染，WHV–DNA水平比发生持续感染的对照组的WHV–DNA水平低3–6 log。在这两个土拨鼠和两个自限性感染的对照土拨鼠中均观察到WHeAg血清转化为抗WHe。在四个慢性携带者中的两个中，IGC给药后WHV-DNA水平显着下降（降低了4-6个对数），在随访期间病毒载量没有反弹。在这些动物中也观察到WHeAg血清转化为抗WHe。对来自包膜蛋白的序列的分析证实IGC没有诱导抗性病毒变体的出现。这项研究的结果表明，IGC可能有助于打破肝炎病毒感染的耐受性，并增强宿主的先天性和过继性免疫反应。 J. Med。病毒83：178–186，2011。©2010 Wiley-Liss，Inc.

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