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首页> 外文期刊>Journal of Medical Virology >Human papillomavirus infection among women with cytological abnormalities in Switzerland investigated by an automated linear array genotyping test
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Human papillomavirus infection among women with cytological abnormalities in Switzerland investigated by an automated linear array genotyping test

机译：通过自动线性阵列基因分型测试调查了瑞士具有细胞学异常的女性中的人乳头瘤病毒感染

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摘要

Limited data are available describing human papillomavirus (HPV) genotype distribution among females with cytological abnormalities in Switzerland. Cervical cell specimens obtained from 5,318 women were screened routinely by liquid-based Pap smear. All specimens with cellular abnormalities were analyzed subsequently for HPV DNA by the Linear Array HPV genotyping test. Cellular abnormalities were found in 202 (3.8%) specimens, of which 150 (74.3%) were positive for high-risk (HR) HPV. HR-HPV was detected in 20 (60.6%; 95% CI, 43.7–75.4%) of 33 specimens with atypical squamous cells of undetermined significance compared to 98 (72.1%; 95% CI, 64–78.9%) of 136 low-grade squamous intraepithelial lesions and 32 (97%; 95% CI, 83.4–99.9%) of 33 high-grade squamous intraepithelial lesions. The cumulative prevalence of HR-HPV other than HPV 16 and 18 was significantly higher than HPV 16 and/or 18 lesions with atypical squamous cells and low-grade lesions and was comparable in high-grade squamous intraepithelial lesions. The most common HR-HPV genotypes were HPV 16 (15.2%), HPV 31 (12.1%), HPV 58 (12.1%), HPV 51 (9.1%), and HPV 59 (9.1%) in women with atypical squamous cells, HPV 16 (25%), HPV 51 (16.9%), HPV 52 (11.8%), HPV 31 (9.6%), and HPV 56 (8.1%) in women with low-grade lesions (LSIL) and HPV 16 (57.6%), HPV 18 (18.2%), HPV 31 (15.2%), HPV 52 (12.1%), and HPV 58 (6.1%) in women with high-grade lesions (HSIL). J. Med. Virol. 83:1370–1376, 2011. © 2011 Wiley-Liss, Inc.
机译：有限的数据可用于描述瑞士具有细胞学异常的女性中人乳头瘤病毒（HPV）基因型分布。常规筛查从5318名妇女获得的宫颈细胞标本，进行液基宫颈涂片检查。随后通过线性阵列HPV基因分型测试分析所有细胞异常的标本中的HPV DNA。在202（3.8％）个标本中发现了细胞异常，其中150（74.3％）个高危（HR）HPV阳性。 HR-HPV在33份非典型鳞状细胞标本中有20份（60.6％； 95％CI，43.7–75.4％）被检测出，而136份低水平标本中有98份（72.1％； 95％CI，64–78.9％）被检测到。级鳞状上皮内病变和33例高度鳞状上皮内病变中的32例（97％； 95％CI，83.4–99.9％）。除HPV 16和18外，HR-HPV的累积患病率显着高于具有非典型鳞状细胞和低度病变的HPV 16和/或18病变，在高级别鳞状上皮内病变中可比。在非典型鳞状细胞女性中，最常见的HR-HPV基因型是HPV 16（15.2％），HPV 31（12.1％），HPV 58（12.1％），HPV 51（9.1％）和HPV 59（9.1％），低度病变（LSIL）和HPV 16（57.6）的女性中HPV 16（25％），HPV 51（16.9％），HPV 52（11.8％），HPV 31（9.6％）和HPV 56（8.1％）患有高级别病变（HSIL）的女性中，HPV 18（18.2％），HPV 31（15.2％），HPV 52（12.1％）和HPV 58（6.1％）。 J. Med。病毒83：1370–1376，2011年。©2011 Wiley-Liss，Inc.

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