Measuring the magnetophoretic characteristics of magnetic agents for targeted diagnostic or therapeutic interventions in the vascular network

Guillermo Vidal; Sylvain Martel

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Measuring the magnetophoretic characteristics of magnetic agents for targeted diagnostic or therapeutic interventions in the vascular network

机译：测量磁性药物的磁热特性，以针对血管网络进行有针对性的诊断或治疗干预

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摘要

An experimental setup for characterizing the magnetophoretic properties of magnetic therapeutic microcarriers and/or diagnostic agents is described. Such characterization is essential for determining the optimal sequences of magnetic gradients to deflect its trajectory though relatively complex vascular networks in order to reach a pre-determined target. The recorded magnetophoretic data can be used to predict the path of the agents when submitted to directional gradient fields and under different fluid flow velocities. Automatic extraction of these data is performed using a tracking method.

机译：描述了表征磁性治疗性微载体和/或诊断剂的磁致动特性的实验装置。这种特征对于确定最佳的磁梯度序列以通过相对复杂的血管网络偏转其轨迹以达到预定目标至关重要。当服从方向梯度场并且在不同的流体流速下时，所记录的磁泳数据可以用于预测药剂的路径。使用跟踪方法自动提取这些数据。

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来源
《Journal of Micro - Nano Mechatronics》 |2013年第2期|65-71|共7页
作者
Guillermo Vidal; Sylvain Martel;
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作者单位

1.NanoRobotics Laboratory Department of Computer and Software Engineering École Polytechnique de Montréal (EPM) Montréal Canada;

1.NanoRobotics Laboratory Department of Computer and Software Engineering École Polytechnique de Montréal (EPM) Montréal Canada;

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正文语种 eng
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关键词
Magnetic; Magnetic nanoparticles; Magnetophoresis; Targeted drug delivery; Magnetic aggregations;

机译：磁性;磁性纳米颗粒;磁性渗透性;靶向药物递送;磁性聚集体;

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专利

1. Peptide-based nanosystems for vascular cell adhesion molecule-1 targeting: a real opportunity for therapeutic and diagnostic agents in inflammation associated disorders [J] . Giorgia Ailuno, Sara Baldassari, Guendalina Zuccari, Journal of drug delivery science and technology . 2020,第期

机译：基于尿道的血管细胞粘附分子-1靶向靶向：炎症相关疾病治疗和诊断剂的真正机会
2. Combining Pulsed and DC Gradients in a Clinical MRI-Based Microrobotic Platform to Guide Therapeutic Magnetic Agents in the Vascular Network [J] . Sylvain Martel International Journal of Advanced Robotic Systems . 2013,第1期

机译：在临床基于MRI的微机器人平台中结合脉冲和直流梯度来指导血管网络中的治疗性磁性药物
3. Combining Pulsed and DC Gradients in a Clinical MRI-Based Microrobotic Platform to Guide Therapeutic Magnetic Agents in the Vascular Network [J] . Sylvain Martel International Journal of Advanced Robotic Systems . 2013,第1期

机译：在临床基于MRI的微机器人平台中结合脉冲和直流梯度来指导血管网络中的治疗性磁性药物
4. Targeted ultrasound contrast agents: diagnostic and therapeutic potential [C] . Lindner, J.R. . 2001

机译：靶向超声造影剂：诊断和治疗潜力
5. Therapeutic magnetic microcarriers characterization by measuring magnetophoretic attributes. [D] . Vidal Ibacache, Guillermo. 2013

机译：通过测量磁泳属性来表征治疗性磁性微载体。
6. Magnetically Targeted Delivery of Therapeutic Agents to Injured Blood Vessels for Prevention of In-Stent Stenosis [O] . Michael Chorny, Ilia Fishbein, Richard F. Adamo, 2012

机译：磁靶向治疗药向受伤血管的输送以预防支架内狭窄
7. Combining Pulsed and DC Gradients in a Clinical MRI-Based Microrobotic Platform to Guide Therapeutic Magnetic Agents in the Vascular Network [O] . Sylvain Martel 2013

机译：在基于mRI的临床微机器人平台中结合脉冲和DC梯度来指导血管网络中的治疗性磁性药物

Measuring the magnetophoretic characteristics of magnetic agents for targeted diagnostic or therapeutic interventions in the vascular network

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