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首页> 外文期刊>Journal of Molecular Histology >Tissue distribution and expression of signaling lymphocyte activation molecule receptor to peste des petits ruminant virus in goats detected by real-time PCR
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Tissue distribution and expression of signaling lymphocyte activation molecule receptor to peste des petits ruminant virus in goats detected by real-time PCR

机译：实时荧光定量PCR检测山羊小反刍动物病毒的淋巴细胞活化分子受体的组织分布和表达

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摘要

In the present study, we investigated the tissue distribution and expression of signaling lymphocyte activation molecule (SLAM) in 40 tissues and organs of goats by real-time RT-PCR, in order to determine the role of these receptors in tissue tropism. SLAM mRNA was detected in all the samples investigated. The expression of SLAM mRNA was detected at high levels in spleen, mesenteric lymph node, hilar lymph node, mandibular lymph node, superficial cervical lymph node, nasal mucosa, duodenum, heart, gallbladder, thymus and blood; this is similar to the tissue tropism of peste des petits ruminant virus. However, it was surprising that expression of SLAM was low in lungs, colon and rectum which are the major sites of replication of PPRV. In addition, very low levels were detected in larynx, tongue and esophagus, which suggest the possible presence of an alternative receptor for PPRV. This study provided the first data on caprine SLAM for use in further studies of the pathogenesis of PPRV in goats.
机译：在本研究中，我们通过实时RT-PCR研究了山羊40个组织器官中信号淋巴细胞活化分子（SLAM）的组织分布和表达，以确定这些受体在组织嗜性中的作用。在所有研究样品中均检测到SLAM mRNA。在脾，肠系膜淋巴结，肺门淋巴结，下颌淋巴结，颈浅表淋巴结，鼻粘膜，十二指肠，心脏，胆囊，胸腺和血液中高水平检测到SLAM mRNA的表达；这类似于小反刍动物瘟热病毒的组织嗜性。然而，令人惊奇的是，SLAM在PPRV复制的主要部位-肺，结肠和直肠中的表达较低。此外，在喉，舌和食道中检测到非常低的水平，这表明可能存在PPRV的替代受体。这项研究提供了关于山羊SLAM的首个数据，可用于进一步研究山羊PPRV的发病机理。

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  • 来源
    《Journal of Molecular Histology》 |2011年第5期|p.467-472|共6页
  • 作者

    Xuelian Meng; Yongxi Dou; Junjun Zhai; Hairui Zhang; Fengchao Yan; Xiaoni Shi; Xuelong Luo; Hui Li; Xuepeng Cai;

  • 作者单位

    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of Ministry of Agriculture, Key Laboratory of Veterinary Parasitology of Gansu Province, Gansu Provincial Engineering and Technique Research Centre on Biological Detection, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Yanchangpu, Chengguan District, Lanzhou, 730046, China;

    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of Ministry of Agriculture, Key Laboratory of Veterinary Parasitology of Gansu Province, Gansu Provincial Engineering and Technique Research Centre on Biological Detection, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Yanchangpu, Chengguan District, Lanzhou, 730046, China;

    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory o;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Real-time RT-PCR; SLAM receptor; Expression; Tissue distribution; Goat;

    机译：实时RT-PCR;SLAM受体;表达;组织分布;山羊;

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