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Spatio-temporal specification of olfactory bulb interneurons

机译：嗅球中间神经元的时空规范

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摘要

Olfactory bulb (OB) interneurons are continuously generated throughout development and in adulthood, and are derived from different progenitor zones. Once integrated in the OB circuits, interneurons play essential roles in olfactory information processing by modulating the activity of major output neurons. These functions are performed by multiple classes of neurons that differ in their spatial distribution, morphology, neurochemical and synaptic properties. This diversity, and the continuous neurogenesis make the understanding of the specification mechanisms in the OB a challenging task. New studies suggest that both intrinsic and extrinsic cues are involved in fate determination of OB interneurons. In both development and adulthood the expression of specific transcription factors not only defines different progenitor regions but also precise interneuronal phenotypes. Here we discuss recent findings on the molecular mechanisms regulating production and diversity of OB interneurons with respect to the spatial and temporal parameters.
机译：嗅球（OB）中间神经在整个发育过程中和成年期不断产生，并且源自不同的祖细胞区。一旦整合到OB电路中，中间神经元就会通过调节主要输出神经元的活动在嗅觉信息处理中发挥重要作用。这些功能由多种神经元执行，这些神经元的空间分布，形态，神经化学和突触特性不同。这种多样性以及持续的神经发生使得对OB中规范机制的理解成为一项艰巨的任务。新的研究表明，内在和外在暗示都与OB中间神经元的命运确定有关。在发育和成年期，特定转录因子的表达不仅定义了不同的祖细胞区域，而且还定义了精确的神经元间表型。在这里，我们讨论有关调控OB interneurons的生产和多样性的分子机制关于空间和时间参数的最新发现。

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  • 来源
    《Journal of Molecular Histology》 |2007年第6期|563-569|共7页
  • 作者

    Serena Bovetti; Paolo Peretto; Aldo Fasolo; Silvia De Marchis;

  • 作者单位

    Department of Animal and Human Biology University of Turin Via Accademia Albertina 13 Turin 10123 Italy;

    Department of Animal and Human Biology University of Turin Via Accademia Albertina 13 Turin 10123 Italy;

    Department of Animal and Human Biology University of Turin Via Accademia Albertina 13 Turin 10123 Italy;

    Department of Animal and Human Biology University of Turin Via Accademia Albertina 13 Turin 10123 Italy;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Olfactory bulb; Specification; Interneuron; Neurogenesis; SVZ; LGE;

    机译：嗅球;规格;神经元;神经发生;SVZ;LGE;

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