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首页> 外文期刊>Journal of Molecular Neuroscience >Comparison of the Temporary Dynamics of NGF and BDNF Gene Expression in Rat Hippocampus, Frontal Cortex, and Retina Under Semax Action
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Comparison of the Temporary Dynamics of NGF and BDNF Gene Expression in Rat Hippocampus, Frontal Cortex, and Retina Under Semax Action

机译：Semax作用下大鼠海马，额叶皮层和视网膜中NGF和BDNF基因表达的暂时动态比较

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摘要

Neurotrophins are a family of structurally related proteins that regulate the survival, differentiation, and maintenance of function of different neuron populations. Some peptides are able to affect the production and activity of neurotrophins. One of these synthetic peptides is heptapeptide Semax, an analog of the N-terminal adrenocorticotropic hormone fragment 4-10. It is known that Semax has effects on learning and memory formation and exerts some neuroprotective effects in rodents and humans. Male Wistar rats were treated for 20 min, 40 min, 90 min, 3 h, 8 h, and 24 h with Semax. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in rat brain and retina was analyzed by real-time polymerase chain reaction. It was revealed that after Semax administration the multidirectional activation of the expression of the genes under investigation in the hippocampus, frontal cortex, and retina was observed. The expression of both neurotrophin genes was decreased in rat hippocampus and retina 20 min after Semax administration and was increased in the frontal cortex. The expression levels of NGF remained practically constant in the retina at the initial stage, whereas the expression levels of BDNF were significantly increased 90 min after Semax administration.
机译：神经营养蛋白是一系列结构相关的蛋白质，可调节不同神经元群体的存活，分化和维持功能。一些肽能够影响神经营养蛋白的产生和活性。这些合成肽之一是七肽Semax，它是N端促肾上腺皮质激素片段4-10的类似物。众所周知，Semax对学习和记忆形成有影响，并在啮齿动物和人类中发挥一些神经保护作用。用Semax将雄性Wistar大鼠治疗20分钟，40分钟，90分钟，3小时，8小时和24小时。通过实时聚合酶链反应分析了大鼠大脑和视网膜中的神经生长因子（NGF）和脑源性神经营养因子（BDNF）基因表达。揭示了在给予Semax后，在海马，额叶皮层和视网膜中观察到了所研究基因的表达的多向激活。 Semax给药20分钟后，大鼠海马和视网膜中两种神经营养蛋白基因的表达均降低，而额叶皮质中的表达均升高。在Semax给药90分钟后，视网膜中NGF的表达水平实际上保持恒定，而BDNF的表达水平则显着增加。

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  • 来源
    《Journal of Molecular Neuroscience》 |2010年第1期|p.30-35|共6页
  • 作者

    Maria Shadrina; Timur Kolomin; Tamara Agapova; Yan Agniullin; Stanislav Shram; Petr Slominsky; Svetlana Lymborska; Nikolay Myasoedov;

  • 作者单位

    The Laboratory of Molecular Genetics of Hereditary Diseases, Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics RAS, 2 Kurchatov Sq., Moscow, 123182, Russia;

    The Laboratory of Molecular Genetics of Hereditary Diseases, Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics RAS, 2 Kurchatov Sq., Moscow, 123182, Russia;

    The Laboratory of Molecular Genetics of Hereditary Diseases, Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics RAS, 2 Kurchatov Sq., Moscow, 123182, Russia;

    The Laboratory of Isotope-Labeled Physiologically Active Compounds, Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics RAS, 2 Kurchatov Sq., Moscow, 123182, Russia;

    The Laboratory of Isotope-Labeled Physiologically Active Compounds, Department of Chemistry of Physiologically Active Compounds,;

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  • 正文语种 eng
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  • 关键词

    Brain-derived neurotrophic factor (BDNF); Nerve growth factor (NGF); ACTH; Semax; Gene expression;

    机译：脑源性神经营养因子（BDNF）;神经生长因子（NGF）;ACTH;Semax;基因表达;

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